| The use of immunohistochemistry for evaluating the liver. | |
| | |
MedLine Citation:
|
PMID: 8839276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Immunohistochemistry has been utilized in recent years primarily for diagnosis of infectious diseases of the liver, especially in humans. The utility of immunohistochemistry has extended to experimental and toxicologic pathology in a variety of areas: identification of cell phenotype, cell receptors, cytokine and chemikine production, and functional cell changes such as enzyme induction. In addition, markers for experimental carcinogenesis studies are detectable by immunohistochemical changes as well as novel antigen induction such as placental glutathione-S-transferase, oncofetal proteins, oncogene products, and typing of neoplasms. Immunohistochemistry is also used to detect the origin and function of various cell types in developmental and toxicity studies. Careful use of immunohistochemical procedures in conjunction with routine pathology and molecular techniques enhance the ability of the toxicologic pathologist to diagnose unique conditions and to understand mechanisms of lesion development. |
| | |
Authors:
|
W C Hall; J L Rojko |
Related Documents
:
|
15713426 - Effect of s-adenosyl-l-methionine on the activation, proliferation and contraction of h... 4090976 - Proliferation of ito cells (fat-storing cells) in acute carbon tetrachloride liver inju... 7218016 - In vivo assessment of phagocytic properties of kupffer cells. 9565106 - Resolution of spur cell anemia with liver transplantation: a case report and review of ... 637836 - Changes in the lactate dehydrogenase isoenzyme pattern during differentiation of rabbit... 17289936 - Identifying nonselective hits from a homogeneous calcium assay screen. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Toxicologic pathology Volume: 24 ISSN: 0192-6233 ISO Abbreviation: Toxicol Pathol Publication Date: 1996 Jan-Feb |
Date Detail:
|
Created Date: 1996-12-17 Completed Date: 1996-12-17 Revised Date: 2009-07-01 |
Medline Journal Info:
|
Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4-12 Citation Subset: IM |
Affiliation:
|
Pathology Associates International, Frederick, Maryland 21701, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Immunohistochemistry / methods* Liver / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Islet cell transplantation in diabetes mellitus--from bench to bedside.
Next Document: Polymerase chain reaction and in situ hybridization: applications in toxicological pathology.