| The use of imiquimod 5% cream for the treatment of basal cell carcinoma as observed in Gorlin's syndrome. | |
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MedLine Citation:
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PMID: 14616807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gorlin's syndrome (naevoid basal cell carcinoma) is an autosomal dominant tumour-predisposition syndrome. It typically consists of multiple basal cell carcinomas (BCCs) of the skin, odontogenic keratocysts of the jaw, various skeletal abnormalities and lamellar falx calcifications. Four patients with multiple facial and trunk BCCs (superficial and nodular) consistent with Gorlin's syndrome are reported. Imiquimod 5% cream was topically applied to the lesions 3-5 times a week for 8-14 weeks. Two of the patients suffered mild to severe erythema and developed superficial erosions but did not discontinue treatment. Imiquimod 5% cream successfully treated 13 out of 17 BCCs in these patients with Gorlin's syndrome, with no patient suffering a relapse at the follow-up visit. |
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Authors:
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G Micali; F Lacarrubba; M R Nasca; R De Pasquale |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 28 Suppl 1 ISSN: 0307-6938 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-17 Completed Date: 2004-02-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 19-23 Citation Subset: IM |
Affiliation:
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Dermatology Clinic, University of Catania, Catania, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage* Adult Aged Aminoquinolines / administration & dosage* Basal Cell Nevus Syndrome / drug therapy* Carcinoma, Basal Cell / drug therapy Facial Neoplasms / drug therapy* Female Humans Male Middle Aged Ointments Skin Neoplasms / drug therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Aminoquinolines; 0/Ointments; 99011-02-6/imiquimod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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