Document Detail

The use of iloprost in early pregnancy in patients with pulmonary arterial hypertension.
MedLine Citation:
PMID:  15994404     Owner:  NLM     Status:  MEDLINE    
In patients with pulmonary hypertension, pregnancy is associated with a high risk of maternal death. Such patients are counselled to avoid pregnancy, or if it occurs, are offered early interruption. Some patients, however, decide to continue with their pregnancy and others may present with symptoms for the first time whilst pregnant. Pulmonary vasodilator therapy provides a treatment option for these high-risk patients. The present study describes three patients with pulmonary arterial hypertension of various aetiologies who were treated with the prostacyclin analogue iloprost during pregnancy, and the post-partum period. Nebulised iloprost commenced as early as 8 weeks of gestation and patients were admitted to hospital between 24-36 weeks of gestation. All pregnancies were completed with a duration of between 25-36 weeks and all deliveries were by caesarean section under local anaesthetic. All patients delivered children free from congenital abnormalities, and there was no post-partum maternal or infant mortality. In conclusion, although pregnancy is strongly advised against in those with pulmonary hypertension, the current authors have achieved a successful outcome for mother and foetus with a multidisciplinary approach and targeted pulmonary vascular therapy.
C A Elliot; P Stewart; V J Webster; G H Mills; S P Hutchinson; E S Howarth; F A Bu'lock; R A Lawson; I J Armstrong; D G Kiely
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  26     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2005-10-18     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK.
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MeSH Terms
Administration, Inhalation
Cesarean Section
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Hypertension, Pulmonary / diagnosis,  drug therapy*
Iloprost / therapeutic use*
Postpartum Period
Pregnancy Complications, Cardiovascular / diagnosis,  drug therapy*
Pregnancy Outcome*
Pregnancy Trimester, First
Risk Assessment
Sampling Studies
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:

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