| The use of iloprost in early pregnancy in patients with pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 15994404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In patients with pulmonary hypertension, pregnancy is associated with a high risk of maternal death. Such patients are counselled to avoid pregnancy, or if it occurs, are offered early interruption. Some patients, however, decide to continue with their pregnancy and others may present with symptoms for the first time whilst pregnant. Pulmonary vasodilator therapy provides a treatment option for these high-risk patients. The present study describes three patients with pulmonary arterial hypertension of various aetiologies who were treated with the prostacyclin analogue iloprost during pregnancy, and the post-partum period. Nebulised iloprost commenced as early as 8 weeks of gestation and patients were admitted to hospital between 24-36 weeks of gestation. All pregnancies were completed with a duration of between 25-36 weeks and all deliveries were by caesarean section under local anaesthetic. All patients delivered children free from congenital abnormalities, and there was no post-partum maternal or infant mortality. In conclusion, although pregnancy is strongly advised against in those with pulmonary hypertension, the current authors have achieved a successful outcome for mother and foetus with a multidisciplinary approach and targeted pulmonary vascular therapy. |
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Authors:
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C A Elliot; P Stewart; V J Webster; G H Mills; S P Hutchinson; E S Howarth; F A Bu'lock; R A Lawson; I J Armstrong; D G Kiely |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 26 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-04 Completed Date: 2005-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Denmark |
Other Details:
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Languages: eng Pagination: 168-73 Citation Subset: IM |
Affiliation:
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Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Cesarean Section Dose-Response Relationship, Drug Drug Administration Schedule Female Follow-Up Studies Humans Hypertension, Pulmonary / diagnosis, drug therapy* Iloprost / therapeutic use* Postpartum Period Pregnancy Pregnancy Complications, Cardiovascular / diagnosis, drug therapy* Pregnancy Outcome* Pregnancy Trimester, First Risk Assessment Sampling Studies Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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78919-13-8/Iloprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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