| The use of hyperventilation and its impact on cerebral ischemia in the treatment of traumatic brain injury. | |
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MedLine Citation:
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PMID: 9012580 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Traumatic brain injury is a common occurrence in the United States, leading to approximately 190,000 deaths or long-term disabilities. Following the primary insult, secondary disturbances in cerebral blood flow (CBF) and metabolism may have deleterious effects on potentially viable neurons. Recent studies evaluating CBF immediately following head injury have revealed flows low enough to produce cerebral ischemia. Hyperventilation is used routinely to lower suspected increased intracranial pressure (ICP). Aggressive hyperventilation produces a marked reduction in CBF, which may give rise to or exacerbate cerebral ischemia, thus enhancing rather than reducing secondary injury. This article reviews the role of hyperventilation in the treatment of increased ICP and its impact on cerebral ischemia following traumatic brain injury. |
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Authors:
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K D Yundt; M N Diringer |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Critical care clinics Volume: 13 ISSN: 0749-0704 ISO Abbreviation: Crit Care Clin Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-03-25 Completed Date: 1997-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8507720 Medline TA: Crit Care Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 163-84 Citation Subset: IM |
Affiliation:
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Department of Neurological Surgery, Washington University, School of Medicine, St. Louis, Missouri, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Injuries / complications*, metabolism*, therapy* Brain Ischemia / etiology*, metabolism*, therapy* Cerebrovascular Circulation Homeostasis / physiology Humans Intracranial Pressure Oxygen / metabolism* Respiration, Artificial* |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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