| The use of human glutathione S-transferase A1 in the detection of cystic fibrosis liver disease. | |
| | |
MedLine Citation:
|
PMID: 9727173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the value of serum human glutathione S-transferase A1 (hGST A1) in the detection of cystic fibrosis liver disease (CFLD). METHODS: Sixty-three children (aged 0.5-16 years) with cystic fibrosis (CF) were screened prospectively for evidence of hepatobiliary abnormalities between February 1993 and February 1996. Comparison was made between clinical examination, abdominal ultrasonic scan, measurement of conventional liver enzymes (LFTs) and serum hGST A1 concentration in the detection of hepatobiliary abnormalities in children with CF. RESULTS: The 5-95% concentration of serum hGST A1 was 1.7-4.27 micrograms L-1 for the control group. The hGST A1 levels in the CF patients were significantly higher than in the non-CF group. Thirty-eight (60%) children had detectable hepatobiliary abnormalities. Ultrasound scanning detected the highest number of abnormalities (41%), followed by hGST A1 (30%). The presence of clinical liver disease was found in 19% of the children. The estimated sensitivities of detecting CFLD by clinical method, ultrasound scan, serum hGST A1, and LFTs would be 32%, 68%, 50% and 16%, respectively. CONCLUSIONS: Serum hGST A1 measurement increases the sensitivity of detecting hepatic abnormalities when included with clinical and ultrasound evaluation although, in some cases with advanced liver disease, serum hGST A1 may be normal. Conventional liver enzyme tests add little information in the detection of CF liver disease. |
| | |
Authors:
|
J C Hung; A F Howie; G J Beckett; M Sood; G Hambleton; M Super |
Related Documents
:
|
10411773 - Fatal pulmonary haemorrhage during anaesthesia for bronchial artery embolization in cys... 21572053 - The effect of recurrent severe hypoglycemia on cognitive performance in children with t... 3526303 - Nesidioblastosis associated with congenital malformations of the heart. morphological a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of paediatrics and child health Volume: 34 ISSN: 1034-4810 ISO Abbreviation: J Paediatr Child Health Publication Date: 1998 Aug |
Date Detail:
|
Created Date: 1999-01-29 Completed Date: 1999-01-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: AUSTRALIA |
Other Details:
|
Languages: eng Pagination: 335-8 Citation Subset: IM |
Affiliation:
|
Royal Manchester Children's Hospital, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Biological Markers / blood Case-Control Studies Child Child, Preschool Clinical Enzyme Tests Confidence Intervals Cystic Fibrosis / blood*, complications Female Glutathione Transferase / blood* Humans Infant Liver Diseases / blood, diagnosis*, etiology Male Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; EC 2.5.1.18/Glutathione Transferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postural drainage in cystic fibrosis: is there a link with gastro-oesophageal reflux?
Next Document: Measles immunity and immunization status in under-5-year-old children in New South Wales: a populati...