Document Detail

The use of hCG and other pregnancy proteins in the diagnosis of ectopic pregnancy.
MedLine Citation:
PMID:  2438075     Owner:  NLM     Status:  MEDLINE    
Early diagnosis of ectopic pregnancy has been greatly improved by three diagnostic advances: the development of rapid and highly sensitive pregnancy tests, advances in ultrasound examination, and laparoscopy. The estimation of hCG is clinically superior to the measurement of any other pregnancy protein or biochemical parameter. If an hCG test has a sensitivity of 25 IU/1, then 90-100% of ectopic pregnancies will give a positive result. But, the hCG test cannot distinguish between intrauterine and ectopic pregnancy, and here ultrasonic examination and laparoscopy are routine diagnostic measures to identify the site of trophoblastic activity. If highly sensitive hCG tests are used routinely, they may detect small amounts of hCG so early in ectopic pregnancy that the tubal swelling is missed, or hCG may be reminiscent from trophoblastic activity of a previous regressing intrauterine or ectopic pregnancy. The lesson we learn from such cases is that a patient with an elevated hCG level in whom an intrauterine pregnancy has been excluded should be carefully followed-up as long as hCG remains elevated because of the possibility of an early ectopic pregnancy.
M Seppälä; M Purhonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  30     ISSN:  0009-9201     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
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MeSH Terms
Chorionic Gonadotropin / analysis*,  metabolism
Pregnancy Complications / diagnosis
Pregnancy Proteins / analysis*
Pregnancy, Ectopic / diagnosis*,  therapy
Pregnancy-Associated Plasma Protein-A / analysis
Pregnancy-Specific beta 1-Glycoproteins / analysis
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Pregnancy Proteins; 0/Pregnancy-Specific beta 1-Glycoproteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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