Document Detail

The use of glucan as immunostimulant in the treatment of a severe case of chromoblastomycosis.
MedLine Citation:
PMID:  18444974     Owner:  NLM     Status:  MEDLINE    
We report the case of an alternative treatment for a patient with a severe form of chromoblastomycosis that responded poorly to the traditional antifungal therapy. We hereby show, in this study, the improvement of lesions after treatment with itraconazole associated with an intramuscular administration of glucan. We observed that the regression of lesions was associated with an improvement of the cellular immune response. This favourable response that we observed suggests that the therapeutic regimen we used might be an option for the treatment of patients with a severe form of chromoblastomycosis.
Conceição de Maria Pedrozo e Silva Azevedo; Sirley Garcia Marques; Maria Aparecida Resende; Azizedite Guedes Gonçalves; Daniel Vagner de Castro Lima Santos; Raimunda Ribeiro da Silva; Maria da Glória Teixeira de Sousa; Sandro Rogerio de Almeida
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Publication Detail:
Type:  Case Reports; Letter     Date:  2008-04-28
Journal Detail:
Title:  Mycoses     Volume:  51     ISSN:  1439-0507     ISO Abbreviation:  Mycoses     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-10-14     Completed Date:  2008-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  341-4     Citation Subset:  IM    
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MeSH Terms
Adjuvants, Immunologic / therapeutic use*
Antifungal Agents / therapeutic use*
Chromoblastomycosis / drug therapy*
Drug Therapy, Combination
Glucans / immunology*
Itraconazole / therapeutic use*
Middle Aged
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Antifungal Agents; 0/Glucans; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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