Document Detail

The use of gated cine phase contrast and MR venography in achondroplasia.
MedLine Citation:
PMID:  11048631     Owner:  NLM     Status:  MEDLINE    
OBJECTS: Foramen magnum and jugular foramen stenosis, well-known problems in achondroplasia, may result in brain stem compression and venous outflow obstruction, respectively. We studied a series of children with achondroplasia using gated cine phase contrast (PC) CSF flow studies to evaluate CSF dynamics across the foramen magnum and MR venography (MRV) to depict obstructed venous drainage. METHODS: Ten patients (9 months to 11 years, mean 2.85 years) were referred for possible brain stem compression. MRI included routine sequences, cine PC with velocity encoding (VENC) = 5 cm/s, and MRV. Six patients, including the asymptomatic patient, had brain stem compression without tonsillar herniation; two had tonsillar herniation; and two had neither brain stem compression nor tonsillar herniation. Abnormal tonsillar movement was seen only with tonsillar herniation. MRV showed steno-occlusive disease of the internal jugular vein (IJV) in nine patients, sigmoid sinus in four, and absent or hypoplastic transverse sinus in seven. Veno-occlusive disease was not progressive. No patient had massive hydrocephalus, although larger ventricles were associated with more profuse venous collateral formation and more severe degrees of IJV stenosis. Three patients have undergone CSF diversion. CONCLUSIONS: MR imaging may be useful in defining the pathophysiology of brain stem compression and hydrocephalus in achondroplasia.
N Rollins; T Booth; K Shapiro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  16     ISSN:  0256-7040     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-03-08     Completed Date:  2001-05-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  569-75; discussion 575-7     Citation Subset:  IM    
Department of Radiology, Children's Medical Center, Dallas, TX 75235, USA.
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MeSH Terms
Achondroplasia / diagnosis*
Brain Stem / pathology
Cerebral Ventricles / pathology
Child, Preschool
Constriction, Pathologic / pathology
Foramen Magnum / pathology
Magnetic Resonance Imaging, Cine / methods*
Phlebography / methods*

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