| The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. | |
| | |
MedLine Citation:
|
PMID: 8200197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A substantial disturbance of the metabolism of the n-6 essential fatty acids (EFAs) exists in both human and experimental diabetes mellitus. The process of conversion of dietary linoleic acid to gammalinolenic, dihomogammalinolenic and arachidonic acids, and other polyunsaturates is inadequate in diabetic patients. Disturbances of these EFAs and the 1- and 2-series prostaglandins derived from them cause a variety of microvascular, haemorheological, and other abnormalities leading to reduced blood flow and neural hypoxia. This will in turn produce an escalating cycle of further hypoxia through the generation of oxygen-free radicals and aggravation of neural capillary endothelial damage. Endoneurial hypoxia impairs axonal transport, produces demyelination, and reduces neural ATP-ase activity. Furthermore, depletion of polyunsaturated fatty acids derived from n-6 pathway may lead to abnormalities of myelin turnover, membrane-bound proteins (such as enzymes and receptors) and other axonal structural abnormalities. The disorders postulated here may synergistically interact with the metabolic changes described in both the glycosylation and the myoinositol hypotheses and may have important implications in the approach to treat diabetic neuropathy. |
| | |
Authors:
|
G A Jamal |
Related Documents
:
|
10380117 - Cross-influence of membrane polyunsaturated fatty acids and hypoxia-reoxygenation on al... 12853447 - Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha a... 15649777 - Fatty acid compositions of collembola: unusually high proportions of c20 polyunsaturate... 1527477 - Transport of n-3 fatty acids from the intestine to the retina in rats. 1595087 - Inhibition of human term placental and fetal liver glutathione-s-transferases by fatty ... 1585407 - Effect of food on salsalate absorption. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 11 ISSN: 0742-3071 ISO Abbreviation: Diabet. Med. Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-07-07 Completed Date: 1994-07-07 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 145-9 Citation Subset: IM |
Affiliation:
|
Glasgow University Department of Neurology, Institute of Neurological Sciences, Scotland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diabetes Mellitus
/
metabolism Diabetic Neuropathies / physiopathology, prevention & control*, therapy* Dietary Fats* Fatty Acids, Essential / metabolism Humans Models, Biological gamma-Linolenic Acid / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 0/Fatty Acids, Essential; 506-26-3/gamma-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Respiratory failure as a result of drugs, overdoses, and poisonings.
Next Document: Blood pressure, diet and the progression of nephropathy in patients with type 1 diabetes and hyperte...