Document Detail

The use of fluoxetine in Gilles de la Tourette syndrome and obsessive compulsive behaviours: preliminary clinical experience.
MedLine Citation:
PMID:  8843495     Owner:  NLM     Status:  MEDLINE    
1. Obsessive Compulsive Behaviours (OCB) occur in more than 50% of patients with the Gilles de la Tourette Syndrome (GTS) and in some cases these behaviours are more disabling than the tics themselves. 2. Fluoxetine, a specific serotonin reuptake inhibitor (SSRI) has been demonstrated to be effective in patients with Obsessive Compulsive Disorder. 3. The authors report on their clinical experience of fluoxetine in 30 GTS patients with OCB, in an open retrospective study. 4. There was an overall improvement in OCB as judged by the clinician in 76% of cases. Most patients received fluoxetine at a daily dose of 20 to 40mg for an average period of 6 months (24 +/- 4 weeks). In general, fluoxetine was well tolerated and further studies are indicated.
V Eapen; M R Trimble; M M Robertson
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  20     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-01-03     Completed Date:  1997-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  737-43     Citation Subset:  IM    
Department of Neuropsychiatry, Institute of Neurology, London, UK.
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MeSH Terms
Antidepressive Agents, Second-Generation / adverse effects,  therapeutic use*
Child, Preschool
Family Practice
Fluoxetine / adverse effects,  therapeutic use*
Obsessive-Compulsive Disorder / drug therapy*,  psychology
Psychiatric Status Rating Scales
Retrospective Studies
Tourette Syndrome / drug therapy*,  psychology
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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