| The use of enteric-coated mycophenolate sodium in the treatment of relapsing and steroid-dependent minimal change disease. | |
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MedLine Citation:
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PMID: 18264946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on the successful treatment of 5 consecutive adult patients with steroid-dependent or frequently relapsing minimal change disease (MCD), using a regimen of enteric-coated mycophenolate sodium (E-MPS) and prednisolone. E-MPS was used for induction therapy in 3 patients, and maintenance therapy in 2, all in conjunction with steroid treatment in tapering doses. Eventually 4 patients managed to discontinue steroid treatment, and 2 of them were also withdrawn from E-MPS. This combination therapy resulted in sustained remission and was well tolerated by our patients, with no signs of gastrointestinal upset, marrow suppression or increased incidence of infections. Our preliminary experience suggests that E-MPS is a promising new alternative in the management of steroid-dependent and relapsing MCD with a possibility of improving gastrointestinal tolerance. |
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Authors:
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Yui-Pong Siu; Matthew Ka-Hang Tong; K ayTai Leung; Tze-Hoi Kwan; Tak-Cheung Au |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of nephrology Volume: 21 ISSN: 1121-8428 ISO Abbreviation: J. Nephrol. Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: Italy |
Other Details:
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Languages: eng Pagination: 127-31 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong - China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Adult Female Humans Immunosuppressive Agents / therapeutic use* Male Middle Aged Mycophenolic Acid / administration & dosage, therapeutic use* Nephrosis, Lipoid / drug therapy* Recurrence Tablets, Enteric-Coated |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents; 0/Tablets, Enteric-Coated; 24280-93-1/Mycophenolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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