Document Detail


The use of enteric-coated mycophenolate sodium in the treatment of relapsing and steroid-dependent minimal change disease.
MedLine Citation:
PMID:  18264946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report on the successful treatment of 5 consecutive adult patients with steroid-dependent or frequently relapsing minimal change disease (MCD), using a regimen of enteric-coated mycophenolate sodium (E-MPS) and prednisolone. E-MPS was used for induction therapy in 3 patients, and maintenance therapy in 2, all in conjunction with steroid treatment in tapering doses. Eventually 4 patients managed to discontinue steroid treatment, and 2 of them were also withdrawn from E-MPS. This combination therapy resulted in sustained remission and was well tolerated by our patients, with no signs of gastrointestinal upset, marrow suppression or increased incidence of infections. Our preliminary experience suggests that E-MPS is a promising new alternative in the management of steroid-dependent and relapsing MCD with a possibility of improving gastrointestinal tolerance.
Authors:
Yui-Pong Siu; Matthew Ka-Hang Tong; K ayTai Leung; Tze-Hoi Kwan; Tak-Cheung Au
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of nephrology     Volume:  21     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  127-31     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Department of Medicine, Tuen Mun Hospital, Tuen Mun, Hong Kong - China.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Adult
Female
Humans
Immunosuppressive Agents / therapeutic use*
Male
Middle Aged
Mycophenolic Acid / administration & dosage,  therapeutic use*
Nephrosis, Lipoid / drug therapy*
Recurrence
Tablets, Enteric-Coated
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Immunosuppressive Agents; 0/Tablets, Enteric-Coated; 24280-93-1/Mycophenolic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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