| The use of eidronate disodium in the prevention of heterotopic ossification in burn patients. | |
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MedLine Citation:
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PMID: 17869001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heterotopic ossification (HO) is a well-known complication of moderate and severe burn injuries. The development and progression of HO in burn patients are poorly understood phenomena at this time. Numerous measures aimed at preventing or minimizing HO have been described, but no definitive prophylactic modality has been found. Biphosphonate compounds are known to inhibit calcification, but previous studies are equivocal regarding their effectiveness in preventing HO in burn patients. We retrospectively reviewed the effect of etidronate disodium (EDHP), a bisphosphonate, on the development of HO in severely burned patients. We found that not only was EDHP ineffective in preventing HO, the group of patients treated with EDHP demonstrated an increased incidence of HO over that seen in a comparison group. This was true after controlling for age, sex, and %TBSA burned. Based on the results of this study, the routine use of etidronate disodium to prevent HO in burn patients cannot be recommended. |
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Authors:
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David M Shafer; Curt Bay; Daniel M Caruso; Kevin N Foster |
Publication Detail:
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Type: Journal Article Date: 2007-09-14 |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 34 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-03-18 Completed Date: 2008-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 355-60 Citation Subset: IM |
Affiliation:
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Mayo Clinic Department of Plastic and Reconstructive Surgery, Rochester, MN, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Density Conservation Agents / therapeutic use* Burns / complications* Epidemiologic Methods Etidronic Acid / therapeutic use* Female Humans Male Ossification, Heterotopic / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Bone Density Conservation Agents; 2809-21-4/Etidronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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