Document Detail


The use of diltiazem hydrochloride in cardiovascular disorders.
MedLine Citation:
PMID:  6763199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect, and little to no negative inotropic effect in patients with normal ventricular function. Diltiazem has potential use in a wide variety of cardiovascular disorders. It has been shown extremely effective in relieving the coronary artery spasm associated with variant angina. When compared with nitrates in patients with exertional angina, diltiazem has similar efficacy. Preliminary work indicates it will have a therapeutic role in the treatment of unstable angina. Because of its ability to improve the balance between myocardial oxygen supply and demand and reduce cellular injury secondary to ischemia, it is likely that diltiazem will be of benefit in the treatment of acutely ischemic myocardium during cardiopulmonary bypass and possibly acute myocardial infarction. It has proven efficacy in treating re-entrant supraventricular tachycardia. Adverse effects are seen in less than 5% of patients, indicating that it is well tolerated.
Authors:
B J McAuley; J S Schroeder
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  2     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / drug therapy
Animals
Arrhythmias, Cardiac / drug therapy
Benzazepines / therapeutic use*
Calcium Channel Blockers / therapeutic use*
Cardiovascular Diseases / drug therapy*
Chemical Phenomena
Chemistry
Coronary Circulation / drug effects
Coronary Disease / drug therapy
Diltiazem / adverse effects,  metabolism,  pharmacology,  therapeutic use*
Heart Conduction System / drug effects
Hemodynamics / drug effects
Humans
Kinetics
Myocardial Contraction / drug effects
Chemical
Reg. No./Substance:
0/Benzazepines; 0/Calcium Channel Blockers; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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