Document Detail


The use of dexamethasone in support of high-altitude ground operations and physical performance: review of the literature.
MedLine Citation:
PMID:  25399369     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: Military Special Operators (SOs) are exposed environmental conditions that can alter judgment and physical performance: uneven terrain, dryness of ambient air, reduction of air density, and a diminished partial pressure of oxygen. The primary purpose of this review was to determine the medical efficacy of dexamethasone as an intervention for the prevention and treatment of high-altitude illness. The secondary purpose was to determine its ability to maintain physical performance of SOs at high altitudes.
METHODS: A search of the literature from 1970 to 2014 was performed, locating 61 relevant articles, with 43 addressing the primary and secondary purposes of this literature review.
CONCLUSIONS: The review indicates that dexamethasone is an effective prevention and treatment intervention for high-altitude illness. Commonly used dosages of either 2mg every 6 hours or 4mg every 12 hours can prevent high-altitude illnesses in adults. Currently in USSOCOM operations, there is an option to use 4mg every 6 hours (concurrently with acetazolamide 125mg bid) if ascending rapidly to or above 11,500 ft without time for acclimatization. Researchers also determined that acute exposure to high altitude, even in asymptomatic subjects, resulted in small cognitive deficits that could be reversed with dexamethasone. Dexamethasone may also help improve cognition and maximal aerobic capacity in SOs who are susceptible to high-altitude pulmonary edema.
Authors:
Reginald O'Hara; Jennifer Serres; William Dodson; Bruce Wright; Jason Ordway; Eric Powell; Molly Wade
Related Documents :
15892529 - Functional and esthetic rehabilitation in amelogenesis imperfecta with all-ceramic rest...
18059249 - Third canal in the mesial root of permanent mandibular first molars: review of the lite...
12621559 - Mandibular symphyseal contouring in mild mandibular prognathism.
17559459 - Multiple supernumerary teeth in the maxillary canine and mandibular premolar regions: a...
8760839 - Orthodontic treatment of an open bite patient with oral-facial-digital syndrome.
11307199 - Stability of le fort i osteotomy in maxillary inferior repositioning: review of the lit...
16473689 - Kienböck's disease in a 14-year-old gymnast: a case report.
15519879 - Cerebral metastases in malignant mesothelioma: case report and literature review.
12894359 - Oncocytic angiomyolipoma of the kidney: a case report.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of special operations medicine : a peer reviewed journal for SOF medical professionals     Volume:  14     ISSN:  1553-9768     ISO Abbreviation:  J Spec Oper Med     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158402     Medline TA:  J Spec Oper Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
Copyright Information:
2014.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predicting When to Administer Blood Products During Tactical Aeromedical Evacuation: Evaluation of a...
Next Document:  Special forces medical sergeants perceptions and beliefs regarding their current medical sustainment...