| The use of dexamethasone administered to mares at breeding time in the modulation of persistent mating induced endometritis. | |
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MedLine Citation:
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PMID: 18649933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study describes the effect of a single dose of dexamethasone administered to mares at time of breeding. In an initial experiment, the authors investigated safety of treatment. In a second experiment the effect of treatment on the uterine environment, fetal development and pregnancy outcome was examined. In the final part of the study, mares susceptible to persistent mating induced endometritis were identified, by means of a risk factor score system and the effect of treatment evaluated. Results indicated that dexamethasone administered at breeding time did not negatively impact on mares medical and reproductive traits. A reduced inflammatory response was observed post-mating in treated versus control mares and mares with multiple risk factors for susceptibility to persistent mating induced endometritis showed improved pregnancy rates following treatment. The authors concluded that a single dose of dexamethasone administered at the time of breeding is safe and can be used to modulate the uterine inflammatory response to breeding in susceptible mares. |
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Authors:
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S Bucca; A Carli; T Buckley; G Dolci; U Fogarty |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-22 |
Journal Detail:
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Title: Theriogenology Volume: 70 ISSN: 0093-691X ISO Abbreviation: Theriogenology Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-15 Completed Date: 2008-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421510 Medline TA: Theriogenology Country: United States |
Other Details:
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Languages: eng Pagination: 1093-100 Citation Subset: IM |
Affiliation:
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Somerton Equine Hospital, Friarstown, Kildare, Co Kildare, Ireland. stefbucca@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / administration & dosage, therapeutic use Breeding Dexamethasone / administration & dosage*, therapeutic use* Drug Administration Schedule Endometritis / prevention & control, veterinary* Female Horse Diseases / prevention & control* Horses Insemination, Artificial / veterinary Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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