Document Detail


The use of dermal papilla cells in studies of normal and abnormal hair follicle biology.
MedLine Citation:
PMID:  9238318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mesenchyme-derived dermal papilla plays a major regulatory role in the complex cell biology of the hair follicle. The ability to culture dermal papilla cells from a range of species and particularly a range of normal and disordered human hair follicles has enabled the development of a powerful new model system for investigating hair follicle biology. Already these studies have reinforced the importance of dermal papilla cells in initiating new follicle growth and in androgen action in human hair follicles. The retention of hair growth inducing capabilities and characteristics that reflect their in vivo responsiveness to androgens in culture means that they offer a potentially useful approach despite significant drawbacks in working with the cells themselves. Further studies using dermal papilla cells may well elucidate key molecules involved in hair biology in health and disease and, thereby, lead to better therapeutic regimens.
Authors:
V A Randall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Dermatologic clinics     Volume:  14     ISSN:  0733-8635     ISO Abbreviation:  Dermatol Clin     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-08-14     Completed Date:  1997-08-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8300886     Medline TA:  Dermatol Clin     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  585-94     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, University of Bradford, West Yorkshire, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Androgens / physiology
Animals
Cells, Cultured
Hair Follicle / abnormalities*,  physiology*
Humans
Reference Values
Skin / cytology
Skin Physiological Phenomena*
Chemical
Reg. No./Substance:
0/Androgens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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