| The use of cyclosporine in a boy with a prior episode of posterior encephalopathy. | |
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MedLine Citation:
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PMID: 15717165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 12- year-old Japanese boy who was receiving cyclosporine (Cs A) for steroid-dependent nephrotic syndrome despite a prior episode of Cs A-associated posterior encephalopathy. At the third relapsing of nephrotic syndrome, Cs A was initiated. Eight days after the Cs A therapy, the boy was admitted to the University Hospital of Tsukuba because of generalized convulsion. Magnetic resonance imaging (MRI) showed hyperintense lesions involving the bilateral parieto-occipital region. Cs A was discontinued, and cyclophosphamide was started. The boy had a 6-month drug-free period after the cyclophosphamide treatment and then relapsed three more times in the following 5 months. As the prednisolone dosage could not be decreased to less than 2 mg/kg/48 h, the patient was re-challenged with Cs A 1 1/2 years later. Blood pressure and serum Cs A levels were measured frequently, an anti-hypertensive drug was given, and MRI was done four times to detect hyperintense lesions. He has been receiving Cs A for 9 months, and MRI has revealed no abnormalities. At the latest follow-up, dated 12 April 2004, he was in a remissive state of nephrotic syndrome. This is the first report of giving Cs A to a nephrotic child who had a previous history of Cs A-associated posterior encephalopathy. |
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Authors:
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Chieko Nakahara; Naoyuki Hasegawa; Isho Izumi; Katsuyosi Kanemoto; Nobuaki Iwasaki |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-02-17 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 20 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-04-19 Completed Date: 2005-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Hospital Organization Mito Medical Center, Higashihara 3-2-1 Mito, 310-0035, Ibaraki, Japan. c.nakahara.d@mn.hosp.go.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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administration & dosage Child Cyclosporine / administration & dosage*, adverse effects Humans Immunosuppressive Agents / administration & dosage*, adverse effects Magnetic Resonance Imaging Male Nephrotic Syndrome / drug therapy* Neurotoxicity Syndromes / etiology*, pathology Prednisolone / administration & dosage Recurrence Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine |
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