Document Detail

Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative?
MedLine Citation:
PMID:  19302863     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The present study aims to compare strength, healing, and operation time of experimental intestinal anastomoses performed by polyglactin 910 (Vicryl; Ethicon, Edinburgh, United Kingdom) sutures with ethyl-2-cyanoacrylate glue (Pattex; Henkel, Dusseldorf, Germany). MATERIAL AND METHODS: Ninety-six Sprague-Dawley rats were divided into 2 (groups E and L). Each group was further subdivided into 6 subgroups (EA1, EA2, EA3, EB1, EB2, EB3, LA1, LA2, LA3, LB1, LB2, LB3), each containing 8 rats. Intestinal anastomosis was performed by polyglactin 910 sutures in A subgroups and with ethyl-2-cyanoacrylate in B subgroups. The anastomosis was end to end in A1 and B1, side to side in A2 and B2, and end to side in A3 and B3. Time for anastomosis performance (AT) was recorded. In group E, bursting pressures and hydroxyproline levels were determined on the second postoperative day, whereas in group L, the same measurements were made on the sixth postoperative day. One-way analysis of variance was used for analyses of variance in the groups. Quantitative data were analyzed with Student's t test. P value was considered significant at less than .05. RESULTS: There was no significant difference between bursting pressures of subgroup pairs on both postoperative days 2 and 6. Hydroxyproline levels and AT were significantly better in B subgroups. CONCLUSION: Better healing, shorter AT, and equal strength were achieved with ethyl-2-cyanoacrylate compared with polyglactin 910 sutures in intestinal anastomosis in the experimental setting.
Levent Elemen; Nuvit Sarimurat; Bekir Ayik; Seval Aydin; Hafize Uzun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  44     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-23     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-6     Citation Subset:  IM    
Department of Pediatric Surgery, Medical Faculty, Kocaeli University, Kocaeli, Turkey.
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MeSH Terms
Adhesives / therapeutic use*
Anastomosis, Surgical
Cyanoacrylates / therapeutic use*
Intestines / surgery*
Polyglactin 910 / therapeutic use*
Rats, Sprague-Dawley
Tensile Strength
Wound Healing
Reg. No./Substance:
0/Adhesives; 0/Cyanoacrylates; 34346-01-5/Polyglactin 910; 7085-85-0/ethyl 2-cyanoacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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