Document Detail


The use of cord blood for transfusion purposes: current status.
MedLine Citation:
PMID:  19570065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the use of umbilical cord blood (UCB) for transfusion purposes has been proposed decades ago, the employ is still limited. In this article we review studies evaluating UCB collection efficiency and sterility, examine processing and storage of UCB-derived red blood cells (RBC) and discuss clinical studies in which UCB was used for transfusion purposes. Efforts to provide preterm newborns with autologous RBC derived from UCB have not been very successful. UCB collected after full-term deliveries can however easily be processed into RBC products and could be used autologous in case surgery of the neonate is indicated early after birth, or for allogeneic small volume paediatric transfusions. To harvest enough UCB volume, immediate clamping of the umbilical cord is commonly used as standard practice. Although delayed cord clamping has shown to improve the iron status in full-term infants; for small-for-gestational-age infants this has not been demonstrated. In addition, an increased need for phototherapy after delayed clamping exists. Altogether, we could find no disencouraging evidence to collect UCB, which could be processed into an easily available RBC product for paediatric transfusion in resource-restricted countries.
Authors:
C M Khodabux; A Brand
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Publication Detail:
Type:  Journal Article     Date:  2009-06-30
Journal Detail:
Title:  Vox sanguinis     Volume:  97     ISSN:  1423-0410     ISO Abbreviation:  Vox Sang.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2010-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-93     Citation Subset:  IM    
Affiliation:
Sanquin Blood Bank, Department of Research and Development, Leiden, The Netherlands. c.khodabux@sanquin.nl
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MeSH Terms
Descriptor/Qualifier:
Blood Transfusion, Autologous
Erythrocyte Transfusion*
Fetal Blood*
Humans
Infant, Newborn
Infant, Premature*
Infant, Small for Gestational Age*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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