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On the use of conventional and tissue Doppler echocardiography in patients with β-Thalassemia major and myocardial iron-overload: Preliminary data by a single centre study.
MedLine Citation:
PMID:  19564055     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
β-Thalassemia Major (βTM) is a hereditary chronic haemolytic anaemia that requires multiple blood transfusions all along lifetime. Late complication of this treatment is tissue iron overload (IO), mostly located on the reticulo-endothelial system, joints, liver, endocrine glands and the heart. In some patients, IO is responsible for heart failure. Echocardiography allows recognizing preclinical left ventricular dysfunction, which can be related to myocardial IO. Over the last few years, cardiac magnetic resonance imaging has become the gold standard for making diagnosis of myocardial IO, by a specific index of myocardial relaxation time, called T2 star (T2⁎). We enrolled 14 βTM patients, mean aged 37.7±10.4 years, with no signs of heart failure, on treatment with iron chelating agents, in whom we sought to investigate whether conventional and/or tissue Doppler velocity echocardiography could discriminate low T2⁎ value patients. Important findings from this preliminary study likely indicate a low prevalence of myocardial IO (approximately 14%) in regularly treated βTM patients. Tissue Doppler velocity imaging was not able to discriminate these latter patients. On the contrary, isovolumetric relaxation time <60 ms, mitrale E/A velocity ratio >2, and both atrial chambers dilatation were associated with T2⁎ value <20 ms.
Authors:
Cesare de Gregorio; Basilia Piraino; Gaetano Morabito; Carmelo Damiano Salpietro; Sebastiano Coglitore
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Publication Detail:
Type:  Journal Article     Date:  2009-06-28
Journal Detail:
Title:  International journal of cardiology     Volume:  145     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  490-2     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Medicine and Pharmacology, Messina University Medical School, Messina, Italy.
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