Document Detail


The use of computational fluid dynamics in inhaler design.
MedLine Citation:
PMID:  23289401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Computational fluid dynamics (CFD) has recently seen increased use in the design of pharmaceutical inhalers. The use of CFD in the design of inhalers is made difficult by the complex nature of aerosol generation. At present, CFD has provided valuable insight into certain aspects of inhaler performance, though limitations in computational power have prevented the full implementation of numerical methods in the design of inhalers.
AREAS COVERED: This review examines the application of CFD in the design of aerosol drug delivery technologies with a focus on pressurized metered-dose inhalers (pMDI), nebulizers and dry powder inhalers (DPIs). Challenges associated with the application of CFD in inhaler design are discussed along with relevant investigations in the literature. Discussions of discrete element modeling (DEM) and the simulation of pharmaceutical aerosol dispersion are included.
EXPERT OPINION: The extreme complexity of coupled fluid and aerosol dynamics associated with aerosol generation has somewhat limited the use of CFD in inhaler design. Combined CFD--DEM simulations provide a useful tool in the design of DPIs, though aerosol generation in pMDIs and nebulizers has eluded CFD modeling. The most beneficial use of CFD typically occurs when concurrent CFD and experimental analyses are performed, significantly enhancing the knowledge provided by experiment alone.
Authors:
Conor A Ruzycki; Emadeddin Javaheri; Warren H Finlay
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-07
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-05-20     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-23     Citation Subset:  IM    
Affiliation:
University of Alberta, Department of Mechanical Engineering , Edmonton, Alberta T6G 2G8, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Computer Simulation
Drug Delivery Systems / instrumentation*
Dry Powder Inhalers
Equipment Design
Humans
Hydrodynamics*
Metered Dose Inhalers*
Nebulizers and Vaporizers
Chemical
Reg. No./Substance:
0/Aerosols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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