Document Detail

The use of cluster and principal component analysis in the estimation of iron status in term newborns.
MedLine Citation:
PMID:  23039064     Owner:  NLM     Status:  Publisher    
Abstract Objective: To assess the relationship between parameters of iron homeostasis in infants and clinical features characterising newborns and their mothers. Methods: The goal of the present work was to determine nine iron status parameters, i.e. hepcidin, prohepcidin, soluble transferrin receptor, ferritin, total iron binding capacity, unsaturated iron binding capacity, transferrin saturation, erythropoietin and total iron concentration, in the cord blood of 57 term newborns as well as to determine the complete blood count in their mothers. Moreover, an appraisal of the relationships between all of the iron parameters, the mothers' hematological factors and 12 clinical attributes was carried out using both cluster (CA) and principal component analysis (PCA). Results: We found that hepcidin is not correlated with its precursor, but it is strongly positively correlated with the total iron concentration. The CA divided all of the 24 parameters into three clusters and showed that certain clinical features, e.g. the APGAR score, mother's age or parity, are related to the hepcidin and prohepcidin concentration. Conclusion: We demonstrated that CA and PCA are efficacious methods for assessing the relationship between iron metabolism parameters in cord blood and large amounts of clinical characteristics.
Artur Słomka; Piotr Korbal; Natalia Piekuś; Ewa Zekanowska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pathophysiology, Collegium Medicum of Nicolaus Copernicus University, Bydgoszcz, Poland.
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