Document Detail

The use of chromium-51 sodium chromate for the detection of food and chemical sensitivities.
MedLine Citation:
PMID:  629429     Owner:  NLM     Status:  MEDLINE    
Both antibody mediated lysis of human RBC's and toxic hemolysis were found to occur with chemicals used as coloring agents for foods, drugs and cosmetics. Because of the strong chromaticity of these dyes, chromium-51 sodium chromate was bound to the hemoglobin of target human RBC's and its efflux was used as an indicator of lysis instead of spectrophotometry, which had been used with food antigens. The major antibody effect was noted when treatment of the target RBC's with antiIgG resulted in a marked inhibition of lysis, indicating that IgG is a lysis-promoting factor (LPF) in this system. Weaker effects were noted by treatment of the target RBC's with monospecific antisera for the other four classes of immunoglobulin and for alpha2-macroglobulin. No neutralizing effects were observed by pre-incubation of the dyes with autologous serum prior to the addition of RBC's.
L W Mayron; E Kaplan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy     Volume:  40     ISSN:  0003-4738     ISO Abbreviation:  Ann Allergy     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372346     Medline TA:  Ann Allergy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
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MeSH Terms
Chromates / diagnostic use*
Chromium Radioisotopes / diagnostic use*
Drug Hypersensitivity / diagnosis*
Erythrocytes / drug effects
Food Coloring Agents / pharmacology
Food Hypersensitivity / diagnosis*
Immunoglobulin A
Immunoglobulin D
Immunoglobulin M
Reg. No./Substance:
0/Chromates; 0/Chromium Radioisotopes; 0/Food Coloring Agents; 0/Immunoglobulin A; 0/Immunoglobulin D; 0/Immunoglobulin M

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