Document Detail


The use of central neuraxial techniques in parturients with factor V leiden mutation.
MedLine Citation:
PMID:  16301266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The factor V Leiden (FVL) mutation is a leading cause of thrombosis, particularly during pregnancy. During pregnancy, women with thrombotic disorders including FVL are often considered candidates for antepartum anticoagulation with low molecular weight heparin. Pregnancy complications related to thrombosis and the unpredictable timing of labor cause unique challenges with regard to the provision of regional anesthesia. A patient with heterozygotic FVL presenting with thrombotic disease and a complicated anticoagulation status lead us to review 16 additional parturients with FVL. This report focuses on the anesthetic implications that arise in parturients with FVL. We recommend that anesthesiologists be made aware of FVL patients before their due date, anticoagulation with low molecular weight heparin should be transitioned to unfractionated heparin before the 38th gestational week, and multidisciplinary collaborative investigation and care should continue for this disorder.
Authors:
Miriam J Harnett; Mary E Walsh; Thomas F McElrath; Lawrence C Tsen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  101     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2005-12-20     Revised Date:  2006-12-07    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1821-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, Perioperative and Pain Med, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, Obstetrical / methods*
Factor V / genetics*
Female
Heparin / therapeutic use
Humans
Nerve Block / methods*
Point Mutation*
Pregnancy
Pregnancy Complications, Hematologic / prevention & control*
Venous Thrombosis / prevention & control
Chemical
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9005-49-6/Heparin
Comments/Corrections
Comment In:
Anesth Analg. 2006 Dec;103(6):1586-7; author reply 1587-8   [PMID:  17122253 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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