Document Detail

The use of central neuraxial techniques in parturients with factor V leiden mutation.
MedLine Citation:
PMID:  16301266     Owner:  NLM     Status:  MEDLINE    
The factor V Leiden (FVL) mutation is a leading cause of thrombosis, particularly during pregnancy. During pregnancy, women with thrombotic disorders including FVL are often considered candidates for antepartum anticoagulation with low molecular weight heparin. Pregnancy complications related to thrombosis and the unpredictable timing of labor cause unique challenges with regard to the provision of regional anesthesia. A patient with heterozygotic FVL presenting with thrombotic disease and a complicated anticoagulation status lead us to review 16 additional parturients with FVL. This report focuses on the anesthetic implications that arise in parturients with FVL. We recommend that anesthesiologists be made aware of FVL patients before their due date, anticoagulation with low molecular weight heparin should be transitioned to unfractionated heparin before the 38th gestational week, and multidisciplinary collaborative investigation and care should continue for this disorder.
Miriam J Harnett; Mary E Walsh; Thomas F McElrath; Lawrence C Tsen
Related Documents :
22886606 - Evaluation of cardiac performance by abdominal fetal ecg in twin-to-twin transfusion sy...
14961156 - Maternal thrombophilias are not associated with early pregnancy loss.
21806976 - Sequencing circulating mirna in maternal plasma with modified library preparation.
19338986 - Diagnostic factors identified in 1020 women with two versus three or more recurrent pre...
6684046 - Acute leukemia in pregnancy: report of five cases treated with a combination which incl...
2358086 - Treatment of infertility due to retrograde ejaculation: a simple, cost-effective method.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  101     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-22     Completed Date:  2005-12-20     Revised Date:  2006-12-07    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1821-3     Citation Subset:  AIM; IM    
Department of Anesthesia, Perioperative and Pain Med, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, Obstetrical / methods*
Factor V / genetics*
Heparin / therapeutic use
Nerve Block / methods*
Point Mutation*
Pregnancy Complications, Hematologic / prevention & control*
Venous Thrombosis / prevention & control
Reg. No./Substance:
0/factor V Leiden; 9001-24-5/Factor V; 9005-49-6/Heparin
Comment In:
Anesth Analg. 2006 Dec;103(6):1586-7; author reply 1587-8   [PMID:  17122253 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Circulating mature adrenomedullin is related to blood volume in full-term pregnancy.
Next Document:  Continuous femoral nerve blockade or epidural analgesia after total knee replacement: a prospective ...