Document Detail


The use of carbon 11-labeled acetate for assessment of aerobic metabolism.
MedLine Citation:
PMID:  9420698     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carbon 11-labeled acetate has been validated as a tracer of citric acid flux and indirectly of oxidative metabolism. 11C-labeled acetate is predominantly metabolized to 11C-labeled carbon dioxide, which clears from the heart. The myocardial 11CO2 efflux rate that can be estimated by dynamic positron emission tomographic imaging closely correlates with myocardial oxygen consumption over a wide range of flow, substrate use, and metabolic conditions. 11C-labeled acetate clearance rates are indirect indexes of oxidative metabolism. To provide absolute mass fluxes, the 11C-labeled acetate approach would require biochemical validation and configuration of a tracer kinetic model. Clinically, estimates of myocardial oxygen consumption appear to be useful in assessing tissue viability, as shown in patients after acute myocardial infarction or with chronic coronary artery disease. In non-coronary artery disease, 11C-labeled acetate may provide measurement of cardiac efficiency and be useful for monitoring therapy.
Authors:
J A Melin; J L Vanoverschelde; A Bol; G Heyndrickx; W Wijns
Related Documents :
19737388 - Cardiac effects of induction agents in the septic rat heart.
3489478 - Effects of propofol on cardiovascular dynamics, myocardial blood flow and myocardial me...
16919578 - Myocardial oxidative metabolic supply-demand relationships in patients with nonischemic...
23182628 - Biomarkers of myocardial ischemia in the emergency room: cardiospecific troponin and be...
3304698 - Transitions in cardiac isomyosin expression during differentiation of the embryonic chi...
12801448 - Revised guidelines for the management of non-st-segment elevation acute coronary syndro...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  1     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    1994 Mar-Apr
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S48-57     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University of Louvain Medical School, Brussels, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetic Acid / metabolism*
Aerobiosis
Animals
Carbon Radioisotopes / diagnostic use*
Coronary Disease / metabolism
Humans
Myocardial Reperfusion
Myocardium / metabolism*
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Current status of viability assessment with positron tomography.
Next Document:  Experimental and clinical experience with iodine 123-labeled iodophenylpentadecanoic acid in cardiol...