Document Detail

The use of carbon 11-labeled acetate for assessment of aerobic metabolism.
MedLine Citation:
PMID:  9420698     Owner:  NLM     Status:  MEDLINE    
Carbon 11-labeled acetate has been validated as a tracer of citric acid flux and indirectly of oxidative metabolism. 11C-labeled acetate is predominantly metabolized to 11C-labeled carbon dioxide, which clears from the heart. The myocardial 11CO2 efflux rate that can be estimated by dynamic positron emission tomographic imaging closely correlates with myocardial oxygen consumption over a wide range of flow, substrate use, and metabolic conditions. 11C-labeled acetate clearance rates are indirect indexes of oxidative metabolism. To provide absolute mass fluxes, the 11C-labeled acetate approach would require biochemical validation and configuration of a tracer kinetic model. Clinically, estimates of myocardial oxygen consumption appear to be useful in assessing tissue viability, as shown in patients after acute myocardial infarction or with chronic coronary artery disease. In non-coronary artery disease, 11C-labeled acetate may provide measurement of cardiac efficiency and be useful for monitoring therapy.
J A Melin; J L Vanoverschelde; A Bol; G Heyndrickx; W Wijns
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  1     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    1994 Mar-Apr
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S48-57     Citation Subset:  IM    
Division of Cardiology, University of Louvain Medical School, Brussels, Belgium.
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MeSH Terms
Acetic Acid / metabolism*
Carbon Radioisotopes / diagnostic use*
Coronary Disease / metabolism
Myocardial Reperfusion
Myocardium / metabolism*
Reg. No./Substance:
0/Carbon Radioisotopes; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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