| The use of canine-specific albumin in dogs with septic peritonitis. | |
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MedLine Citation:
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PMID: 23216837 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To assess changes in serum albumin concentration (ALB), colloid osmotic pressure (COP), and Doppler blood pressure (DBP) following transfusion of 5% lyophilized canine-specific albumin (CSA) in hypoalbuminemic dogs following surgical source control for septic peritonitis. DESIGN: Prospective randomized clinical trial November 2009 - November 2010. SETTING: University teaching hospital. ANIMALS: Fourteen client-owned dogs with hypoalbuminemia (<27 g/L [2.7 g/dL]) following surgical source control for septic peritonitis. INTERVENTIONS: Dogs were randomized to clinician-directed therapy (CDT) and CSA groups. Dogs enrolled in the CSA group received 800 mg/kg of CSA within 24 hours following surgical intervention. MEASUREMENTS AND MAIN RESULTS: At enrollment, ALB, COP, and DBP were not different between groups. ALB, COP, and DBP were significantly increased in the CSA group 2 hours following completion of the transfusion compared with the CDT group (P = 0.0234, 0.0078, 0.0156, respectively). In comparison to the CDT group, there was a significant change in ALB in the CSA group 24 hours after transfusion (P = 0.0039), but no difference in COP (P = 0.3914) or DBP (P = 0.5145). ALB was significantly higher in the CSA group at 24 hours compared with the CDT group (P = 0.0367) At the time of death or discharge, there was no difference between groups regarding ALB, COP, or DBP, but an association between ALB and survival was identified (P = 0.0273). One dog experienced tachypnea during transfusion of CSA; this dog died of unknown respiratory causes 120 hours after transfusion. CONCLUSIONS: The administration of CSA in dogs with septic peritonitis results in an increase in ALB, COP, and DBP 2 hours after administration. An increase in ALB persisted at 24 hours compared with a CDT group. Administration of this product was not associated with owner-reported delayed adverse events in this population of dogs. |
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Authors:
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Elise M Craft; Lisa L Powell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) Volume: 22 ISSN: 1476-4431 ISO Abbreviation: J Vet Emerg Crit Care (San Antonio) Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101152804 Medline TA: J Vet Emerg Crit Care (San Antonio) Country: United States |
Other Details:
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Languages: eng Pagination: 631-9 Citation Subset: IM |
Copyright Information:
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© Veterinary Emergency and Critical Care Society 2012. |
Affiliation:
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From the Department of Clinical Sciences, Veterinary Medical Center, University of Minnesota, St. Paul, MN, 55108. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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