| The use of botulinum type A toxin in the treatment of idiopathic clubfoot: 5-year follow-up. | |
| | |
MedLine Citation:
|
PMID: 19700985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Continued monitoring and reporting of outcomes in clubfoot patients are important for providing an indicator of functional outcomes and surveillance and treatment for problems or recurrences. The purpose of this study is to report the 5-year outcomes of the updated cohort of 44 patients with 65 idiopathic clubfeet treated with manipulation, casting, and Botulinum toxin A (BTX-A). METHODS: As part of the original study, the patients underwent the corrective treatment phase of manipulation and casting followed with BTX-A injection and then the maintenance phase of bracing. The patients were seen at regular intervals and a detailed clinical history was maintained for each patient including ankle range of motion, recurrences, and interventions for recurrences. RESULTS: Mean values for range of motion at the 5-year visit were 22.3 and 17.1 degrees for dorsiflexion with the knee in flexion and extension, respectively. Overall, 48% (31 of 65 clubfeet) successfully responded to a single BTX-A injection and experienced no recurrence over the follow-up period. At least 1 repeat BTX-A injection was required in 34 clubfeet, for an overall recurrence rate of 52%. Surgery was required in 10 clubfeet, and the overall surgical rate was 15.4%. CONCLUSIONS: Idiopathic clubfeet treated with BTX-A continued to show good outcomes at 2 to 5-year follow-up. The experience with this cohort provides support for the effectiveness of BTX-A in the initial correction and continued management of idiopathic clubfoot. LEVEL OF EVIDENCE: Levels III to IV. This is a prospective, nonexperimental clinical study investigating efficacy of an innovative treatment. |
| | |
Authors:
|
Christine M Alvarez; Mary A De Vera; Harpreet Chhina; Linda Williams; Kim Durlacher; Serap Kaga |
Related Documents
:
|
9202565 - Intracavernosal drug-induced erection therapy versus external vacuum devices in the tre... 15116275 - A study on patients treated with polyacrylamide hydrogel injection for facial corrections. 19784845 - Intravitreal loading injection of ganciclovir with or without adjunctive oral valgancic... 18406955 - A prospective randomized controlled trial of injection of dexamethasone versus triamcin... 1642935 - Iv diclofenac in post-thoracotomy pain. 21540205 - Ventilator-associated tracheitis in children: does antibiotic duration matter? |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pediatric orthopedics Volume: 29 ISSN: 1539-2570 ISO Abbreviation: J Pediatr Orthop Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-08-24 Completed Date: 2009-11-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8109053 Medline TA: J Pediatr Orthop Country: United States |
Other Details:
|
Languages: eng Pagination: 570-5 Citation Subset: IM |
Affiliation:
|
Department of Orthopaedics, Faculty of Medicine, University of British Columbia, Vancouver BC, Canada. calvarez@cw.bc.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Ankle Joint
/
physiopathology Botulinum Toxin Type A / therapeutic use* Child Child, Preschool Clubfoot / physiopathology, therapy* Cohort Studies Combined Modality Therapy Female Follow-Up Studies Humans Infant Knee Joint / physiopathology Male Neuromuscular Agents / therapeutic use* Prospective Studies Range of Motion, Articular Recurrence Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Botulinum Toxin Type A; 0/Neuromuscular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effectiveness of botulinum A toxin as an adjunct to the treatment of clubfeet by the Ponseti met...
Next Document: Distal focal femoral deficiency.