Document Detail

The use of boluses of propofol for the management of severe tetanus in a child.
MedLine Citation:
PMID:  19211431     Owner:  NLM     Status:  MEDLINE    
Tetanus is endemic in many developing countries. Although propofol has been proposed for sedation in tetanus, the routine use of this drug has not been clearly documented in published reports. A few studies have reported its beneficial effects but no randomized studies are available. We describe the case of a five-year-old boy who presented with severe tetanus in East Africa. The antispastic therapy consisted of benzodiazepine infusion with the addition of titrated boluses of propofol. Intubation and mechanical ventilation were avoided.
Fabrice Petitjeans; Jean Turc; Olivier Coulet; Marc Puidupin; Olivier Eve; Alain Benois
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Tropical doctor     Volume:  39     ISSN:  0049-4755     ISO Abbreviation:  Trop Doct     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1301706     Medline TA:  Trop Doct     Country:  England    
Other Details:
Languages:  eng     Pagination:  52-3     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care, Desgenettes Military Hospital, 108 bd Pinel, 69003 Lyon, France.
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MeSH Terms
Anesthetics, Intravenous / administration & dosage*,  therapeutic use
Anticonvulsants / administration & dosage,  therapeutic use
Benzodiazepines / administration & dosage,  therapeutic use
Child, Preschool
Propofol / administration & dosage*,  therapeutic use
Severity of Illness Index*
Spasm / prevention & control
Tetanus / drug therapy*,  physiopathology*
Treatment Outcome
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Anticonvulsants; 12794-10-4/Benzodiazepines; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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