Document Detail


The use of biomarkers in cancer prevention
MedLine Citation:
PMID:  16711369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biomarkers in cancer prevention are increasingly important tools in primary prevention and in intervention by chemopreventive agents. Biomarkers can be utilized as indicators of exposures, effects and individual susceptibility to cancer. Sampling of biomarkers in relation to exposure may have a great impact on the reliability of mechanism of action. The recent developments in genomics provides us with an opportunity to investigate simultaneously numerous oncogenes, tumor-suppressor genes, phenotypic changes in proteins and to utilize the same samples for better understanding of possible ways to disrupt carcinogenesis. Identification of high cancer risk biomarkers is possible also by traditional molecular genetics techniques. Chromosomal studies are based on peripheral blood lymphocyte (PBL) cultures, which may present mutation as a cytogenetic change on chromosome structures. International databases are available for evaluation of high cancer risk among those people who are carrying high incidence of chromosomal aberrations. The biomarkers are suitable to indicate the need for intervention in high risk groups. In those cases, where removal of environmental hazards are not efficient enough in preventive measures since genetic damages are irreversible, it may be possible to introduce chemoprevention at the same time, which includes changes in lifestyle, smoking and drinking habits as well as prescription of vitamins, antioxidants, minerals etc. This paper summarizes the current knowledge on biomarkers indicative of high risk groups and/or individual susceptibility measured by different methodologies, mainly based on Hungarian human genotoxic monitoring studies, which may help to understand the use of biomarkers in everyday medical practice.
Authors:
Anna Tompa
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Orvosi hetilap     Volume:  147     ISSN:  0030-6002     ISO Abbreviation:  Orv Hetil     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-06-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0376412     Medline TA:  Orv Hetil     Country:  Hungary    
Other Details:
Languages:  hun     Pagination:  627-36     Citation Subset:  IM    
Affiliation:
Semmelweis Egyetem, Altalános Orvostudományi Kar, Közegészségtani Intézet. tomann@net.sote.hu
Vernacular Title:
Biomarkerek alkalmazása a rákprevencióban.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Aberrations
DNA Damage
Genetic Predisposition to Disease
Genetic Testing / ethics
Humans
Mutation
Neoplasms / blood,  genetics,  immunology,  metabolism*,  prevention & control*
Tumor Markers, Biological / blood,  genetics,  immunology,  metabolism*
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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