Document Detail


On the use of biomarkers for environmental health research.
MedLine Citation:
PMID:  15198487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This article discusses the growing interest in the use of biomarker data in environmental health research and considers some of the challenging statistical issues that arise. We specify a modeling framework that links environmental exposure, biomarkers and outcome, and discuss in conceptual terms how such a formulation could be used to inform dose response modeling for the purpose of quantitative risk assessment. We then analyse some biomarker data from a case-control study designed to elucidate the mechanisms of smoking induced lung cancer. Because of sample size limitations, we use a likelihood-based analysis which subsumes both cohort and case-control designs as special cases. Our analysis allows us to 1) investigate the extent to which the markers explain the pathway from exposure to outcome; 2) quantify the degree to which biomarker data can improve on predicting outcome over and above exposure; and 3) estimate the association among multiple markers.
Authors:
Louise Ryan; Wenzheng Huang; Sally W Thurston; Karl T Kelsey; John K Wiencke; David C Christiani
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Statistical methods in medical research     Volume:  13     ISSN:  0962-2802     ISO Abbreviation:  Stat Methods Med Res     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-16     Completed Date:  2004-09-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9212457     Medline TA:  Stat Methods Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  207-25     Citation Subset:  IM    
Affiliation:
Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. lryan@hsph.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Biological Markers*
Environmental Monitoring*
Humans
Lung Neoplasms / epidemiology
Models, Statistical*
Research Design
Risk Assessment
Grant Support
ID/Acronym/Agency:
5 P42 ES05947/ES/NIEHS NIH HHS; CA48061/CA/NCI NIH HHS; CA74386/CA/NCI NIH HHS; ES00002/ES/NIEHS NIH HHS; ES011027/ES/NIEHS NIH HHS; ES06717/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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