Document Detail

The use of beta-lactam antibiotics in infections--an overview.
MedLine Citation:
PMID:  6597565     Owner:  NLM     Status:  MEDLINE    
Any new antibiotic must be compared with older agents with respect to therapeutic efficacy, protection against infection, toxicity, cost and pharmacokinetic properties. For a new drug to be considered an "advance", it should achieve some definite advantage in one or more of these areas. By expanding their microbiologic activity and by killing many organisms at extremely low concentration, a number of new beta-lactam antibiotics have become useful agents in the therapy of difficult infections, particularly those occurring in patients with generalized immunodeficiencies or those occurring in body sites of localized immunodeficiency. Of additional clinical relevance has been the ability of some of these new drugs to replace the necessity of combination antibiotic therapy, reducing the chances for adverse reactions. To use the new beta-lactam antibiotics properly, one must now know much more than whether an organism is merely resistant or sensitive to the drug. One must know how sensitive and how resistant the bacterium is to the drug and for how long do serum and tissue levels remain above inhibitory or bactericidal concentrations of the drug for the suspected or proven pathogen. Of course, we cannot forget the cost of the drug and its potential for adverse reactions. In brief to prevent or to treat infections, the clinicians must be familiar with the microbiology, pharmacology, toxicology and cost of antibiotics.
R Quintiliani
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases. Supplementum     Volume:  42     ISSN:  0300-8878     ISO Abbreviation:  Scand J Infect Dis Suppl     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-04     Completed Date:  1985-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0251025     Medline TA:  Scand J Infect Dis Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  99-109     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Bacterial Infections / drug therapy*
Cephalosporins / adverse effects,  therapeutic use
Penicillin Resistance
Penicillins / adverse effects,  therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Penicillins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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