| The use of azathioprine in severe adult atopic eczema. | |
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MedLine Citation:
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PMID: 9784039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the use of azathioprine in the treatment of severe adult atopic eczema and review the relevant literature. BACKGROUND: Effective treatment of severe adult atopic eczema may necessitate the use of agents such as systemic steroids, PUVA or cyclosporin, which are associated with significant morbidity. Azathioprine is an effective alternative which can induce disease remission and may be less toxic. METHODS: Ten patients treated with azathioprine 0.7-2.5 mg/kg per day for a minimum period of 12 months were evaluated in a retrospective follow-up study. RESULTS: Clearance or marked improvement was noted in eight patients; three of these later became refractory to the drug. Side-effects were few and were well-tolerated. One patient was found to have lymphoma 8 months after stopping treatment. CONCLUSION: Azathioprine is an effective and cheaper alternative to cyclosporin in the treatment of severe adult atopic eczema. Its long-term toxicity remains unclear. |
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Authors:
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D A Buckley; P Baldwin; S Rogers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the European Academy of Dermatology and Venereology : JEADV Volume: 11 ISSN: 0926-9959 ISO Abbreviation: J Eur Acad Dermatol Venereol Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-12-16 Completed Date: 1998-12-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9216037 Medline TA: J Eur Acad Dermatol Venereol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 137-40 Citation Subset: IM |
Affiliation:
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City of Dublin Skin and Cancer Hospital, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimetabolites / adverse effects, therapeutic use* Azathioprine / adverse effects, therapeutic use* Clinical Trials as Topic Dermatitis, Atopic / drug therapy* Drug Evaluation Female Follow-Up Studies Herpes Labialis / chemically induced Humans Immunoglobulin E / blood, drug effects Lymphopenia / chemically induced Male Middle Aged Retrospective Studies Sleep Stages / drug effects Treatment Outcome gamma-Glutamyltransferase / blood, drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 37341-29-0/Immunoglobulin E; 446-86-6/Azathioprine; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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