Document Detail

The use of atypical antipsychotics in the treatment of catatonia.
MedLine Citation:
PMID:  15964746     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Evidence indicates that classical antipsychotics may aggravate non-malignant and malignant catatonia (MC). Atypical antipsychotics are less likely to cause movement disorders than classical antipsychotics and they are being frequently prescribed in disorders that can be associated with catatonia. Therefore, the important question that arises is whether atypical antipsychotics have a role to play in the treatment of catatonia. MATERIALS AND METHODS: A Medline search was performed to locate papers on the use of atypical antipsychotics in catatonia published between 1970 and 31st December 2004. RESULTS: The literature on the use of atypical antipsychotics in catatonia consists of case reports and retrospective studies. In most cases of non-MC a reduction of the catatonic symptoms is reported upon treatment with atypical antipsychotics. Cases of MC relate mainly to the neuroleptic malignant syndrome (NMS), which is considered as an iatrogenic stuporous variant of MC caused by antipsychotics. CONCLUSION: There are indications that atypical antipsychotics may be useful in non-MC. As a consequence, one should not only focus on the possible extrapyramidal and autonomic side effects of these drugs, but also on the possible beneficial effects on certain brain functions and on the catatonic symptomatology. However, randomized controlled trials are needed to evaluate the effect of these drugs, and caution is advisable, since cases of NMS have been linked to treatment with atypical antipsychotics. There is no evidence to prescribe atypical antipsychotics in MC.
Filip Van Den Eede; Jan Van Hecke; Arjen Van Dalfsen; Bart Van den Bossche; Paul Cosyns; Bernard G C Sabbe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  20     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-20     Completed Date:  2006-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  France    
Other Details:
Languages:  eng     Pagination:  422-9     Citation Subset:  IM    
Collaborative Antwerp Psychiatric Research Institute, CAPRI, University of Antwerp (UA), Campus Drie Eiken/Building T, Universiteitsplein 1, 2610 Antwerp, Belgium.
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MeSH Terms
Antipsychotic Agents / adverse effects,  therapeutic use*
Catatonia / drug therapy*
Neuroleptic Malignant Syndrome / etiology
Reg. No./Substance:
0/Antipsychotic Agents

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