| The use of antifungal therapy in neonatal intensive care. | |
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MedLine Citation:
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PMID: 22341539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Invasive fungal infections remain a significant cause of infection-related mortality and morbidity in preterm infants. Central nervous system involvement is the hallmark of neonatal candidiasis, differentiating the disease's impact on young infants from that among all other patient populations. Over the past decade, the number of antifungal agents in development has grown, but most are not labeled for use in newborns. We summarize the findings of several antifungal studies that have been completed to date, emphasizing those including infant populations. We conclude that more studies are required for antifungals to be used safely and effectively in infants. |
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Authors:
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Daniela Testoni; P Brian Smith; Daniel K Benjamin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-01-11 |
Journal Detail:
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Title: Clinics in perinatology Volume: 39 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-02-20 Completed Date: 2012-06-19 Revised Date: 2013-04-19 |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 83-98 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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adverse effects,
therapeutic use* Candidiasis / drug therapy* Humans Infant, Newborn Infant, Newborn, Diseases / drug therapy Infant, Premature Infant, Premature, Diseases / drug therapy Intensive Care Units, Neonatal* |
| Grant Support | |
ID/Acronym/Agency:
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1K23HD060040-01/HD/NICHD NIH HHS; 1K24HD058735-01/HD/NICHD NIH HHS; 1R01FD003519-01/FD/FDA HHS; 1R01HD057956-02/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; HHSN275201000003I/HD/NICHD NIH HHS; K23 HD060040-01/HD/NICHD NIH HHS; K24 HD058735/HD/NICHD NIH HHS; K24 HD058735-01A1/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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