Document Detail


The use of antifungal therapy in neonatal intensive care.
MedLine Citation:
PMID:  22341539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invasive fungal infections remain a significant cause of infection-related mortality and morbidity in preterm infants. Central nervous system involvement is the hallmark of neonatal candidiasis, differentiating the disease's impact on young infants from that among all other patient populations. Over the past decade, the number of antifungal agents in development has grown, but most are not labeled for use in newborns. We summarize the findings of several antifungal studies that have been completed to date, emphasizing those including infant populations. We conclude that more studies are required for antifungals to be used safely and effectively in infants.
Authors:
Daniela Testoni; P Brian Smith; Daniel K Benjamin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-11
Journal Detail:
Title:  Clinics in perinatology     Volume:  39     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-98     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27705, USA.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / adverse effects,  therapeutic use*
Candidiasis / drug therapy*
Humans
Infant, Newborn
Infant, Newborn, Diseases / drug therapy
Infant, Premature
Infant, Premature, Diseases / drug therapy
Intensive Care Units, Neonatal*
Grant Support
ID/Acronym/Agency:
1K23HD060040-01/HD/NICHD NIH HHS; 1K24HD058735-01/HD/NICHD NIH HHS; 1R01FD003519-01/FD/FDA HHS; 1R01HD057956-02/HD/NICHD NIH HHS; 1R18AE000028-01/AE/ASPE HHS; HHSN275201000003I/HD/NICHD NIH HHS; K23 HD060040-01/HD/NICHD NIH HHS; K24 HD058735/HD/NICHD NIH HHS; K24 HD058735-01A1/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents
Comments/Corrections

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