Document Detail

The use of antibiotic-impregnated fibrin sealant for the prevention of surgical site infection associated with spinal instrumentation.
MedLine Citation:
PMID:  22820952     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to determine if the use of antibiotic-impregnated fibrin sealant (AFS) was effective in preventing surgical site infections (SSI) associated with spinal instrumentation.
METHODS: In a preliminary study, five pieces of vancomycin-impregnated fibrin sealant, five nuts that were not treated with the sealant, and five nuts that were treated with the sealant were subjected to agar diffusion testing. In a clinical study, the rates of deep SSI were compared between 188 patients who underwent procedures involving spinal instrumentation without AFS (group 1) and 196 patients who underwent procedures involving spinal instrumentation with AFS (group 2).
RESULTS: All five pieces of vancomycin-impregnated fibrin sealant and the five nuts treated with the sealant exhibited antimicrobial efficacy, while the five untreated nuts did not exhibit antimicrobial efficacy in the agar diffusion test. In the clinical study, 11 (5.8 %) of the 188 patients in group 1 acquired a deep SSI, while none (0 %) of the 196 patients in group 2 acquired a deep SSI.
CONCLUSION: The present study demonstrated that the application of AFS to spinal instrumentation yielded good clinical outcomes in terms of the prevention of postoperative spinal infections. It is hoped that limiting AFS use to patients requiring spinal instrumentation and those with risk factors for SSI will reduce the overall costs while preventing SSIs.
Katsuhiro Tofuku; Hiroaki Koga; Mitsuhiro Yanase; Setsuro Komiya
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-07-22
Journal Detail:
Title:  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society     Volume:  21     ISSN:  1432-0932     ISO Abbreviation:  Eur Spine J     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-06-04     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9301980     Medline TA:  Eur Spine J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2027-33     Citation Subset:  IM    
Department of Orthopaedic Surgery, Imakiire General Hospital, 4-16 Shimotatsuo, Kagoshima, Japan.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage*
Fibrin Tissue Adhesive / chemistry*,  therapeutic use
Middle Aged
Spinal Fusion / adverse effects*
Surgical Wound Infection / prevention & control*
Vancomycin / administration & dosage*
Young Adult
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Fibrin Tissue Adhesive; 1404-90-6/Vancomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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