Document Detail

The use of alendronate in the treatment of avascular necrosis of the femoral head: follow-up to eight years.
MedLine Citation:
PMID:  19651826     Owner:  NLM     Status:  MEDLINE    
The use of bisphosphonates in the treatment of avascular necrosis of the femoral head is an encouraging but relatively new option with most published data being derived from small trials with limited follow-up. We present a clinicoradiological analysis of 395 hips with avascular necrosis which were treated with oral alendronate for three years with a mean follow-up of four years (1 to 8). Our results show an improvement in the clinical function, a reduction in the rate of collapse and a decrease in the requirement for total hip replacement, compared with the findings of other studies in which no treatment was given. This improvement is particularly marked if the treatment is begun in the pre-collapse stages of the disease. Even in Ficat stage-III hips some benefit was obtained from treatment with alendronate by at least a delay in the need for total hip replacement.
S Agarwala; S Shah; V R Joshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  91     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-08-31     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  1013-8     Citation Subset:  AIM; IM    
P. D. Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai 400016, India.
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MeSH Terms
Administration, Oral
Alendronate / therapeutic use*
Bone Density Conservation Agents / therapeutic use*
Femoral Fractures / prevention & control*
Femur Head Necrosis / drug therapy*
Follow-Up Studies
Middle Aged
Pain Measurement
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Bone Density Conservation Agents; 66376-36-1/Alendronate
Comment In:
Z Orthop Unfall. 2009 Nov-Dec;147(6):657   [PMID:  20017096 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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