Document Detail


The use of agar as a novel filler for monolithic matrices produced using hot melt extrusion.
MedLine Citation:
PMID:  16697170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of filler materials in an extended release monolithic polymer matrix can lead to a vastly altered release profile for the active pharmaceutical ingredient. A range of excipients for use in monolithic matrices have been discussed in the literature. The body of work described in this research paper outlines the use of agar as a novel filler material in a hot melt extruded polymer matrix. Several batches of matrix material were prepared with Diclofenac sodium used as the active pharmaceutical ingredient (API). Agar and microcrystalline cellulose were used as the filler materials in varying ratios, to examine the effect of % filler content as well as filler type on the properties of the hot melt extruded matrix. The resultant extrudates were characterised using steady state parallel plate rheometry, differential scanning calorimetry (DSC) and dissolution testing. The rheometry analysis concluded that the fillers used resulted in an increase in the matrix viscosity. The DSC scans obtained showed negligible effects on the melting behavior of the matrix as a result of the filler inclusion. Dissolution analysis showed that the presence of the fillers resulted in a slower release rate of API than for the matrix alone. The results detailed within this paper indicate that agar is a viable filler for extended release hot melt produced dosage forms.
Authors:
John G Lyons; Declan M Devine; James E Kennedy; Luke M Geever; Patrick O'Sullivan; Clement L Higginbotham
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-05-11
Journal Detail:
Title:  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V     Volume:  64     ISSN:  0939-6411     ISO Abbreviation:  Eur J Pharm Biopharm     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-07     Completed Date:  2007-01-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9109778     Medline TA:  Eur J Pharm Biopharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Affiliation:
Centre for Biopolymer and Biomolecular Research, Athlone Institute of Technology, Westmeath, Ireland. slyons@ait.ie
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MeSH Terms
Descriptor/Qualifier:
Agar / chemistry*
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical / methods*
Delayed-Action Preparations
Diclofenac / pharmacology*
Drug Carriers
Drug Compounding
Drug Delivery Systems*
Particle Size
Polymethacrylic Acids / chemistry
Solubility
Technology, Pharmaceutical / methods*
Temperature
Time Factors
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Drug Carriers; 0/Polymethacrylic Acids; 15307-86-5/Diclofenac; 25086-15-1/methylmethacrylate-methacrylic acid copolymer; 9002-18-0/Agar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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