Document Detail


The use of B-type natriuretic peptides in the detection of myocardial ischemia in settings with rapid access to coronary angiography.
MedLine Citation:
PMID:  17067699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate serial measurements of B-type natriuretic peptide (BNP) and NT-proBNP levels in the detection of myocardial ischemia. A total of 62 consecutive male patients referred for stress echocardiography in a tertiary care cardiology center were enrolled. Inducible myocardial ischemia was detected in 15 patients (24%). BNP and NT-proBNP levels were significantly lower in patients with ischemia compared to those without ischemia throughout exercise testing and during recovery (p<0.05 for all comparisons). Major differences in baseline characteristics including age and higher incidence of comorbidities including hypertension and kidney disease in patients without ischemia apparently outweighed myocardial ischemia as trigger for BNP and NT-proBNP secretion. The same factors may have induced a selection bias in the decision to offer direct coronary angiography or initial stress testing. In conclusion, BNP and NT-proBNP are not helpful in the evaluation of male patients with suspected myocardial ischemia in a tertiary care cardiology center with rapid access to coronary angiography.
Authors:
David Conen; Nikolaus Jander; Dietmar Trenk; Franz-Josef Neumann; Christian Mueller
Related Documents :
19718479 - Levels of von willebrand factor antigen and von willebrand factor cleaving protease (ad...
16685029 - Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac t...
17617749 - The combination of b-type natriuretic peptide and c-reactive protein provides increment...
17964349 - Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment fo...
15477419 - Prognostic significance of the long pentraxin ptx3 in acute myocardial infarction.
12399629 - Comparison of plasma levels of mature adrenomedullin and natriuretic peptide as markers...
8877429 - Dilatation of sinus of valsalva with displacement and compression of the left coronary ...
1711599 - Persistent cardioprotection by azapropazone in a canine model of coronary artery thromb...
3115119 - Little carbon dioxide diffusional shunting in coronary circulation.
Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2006-10-24
Journal Detail:
Title:  International journal of cardiology     Volume:  119     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  416-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Cohort Studies
Coronary Angiography
Echocardiography, Stress
Humans
Male
Middle Aged
Myocardial Ischemia / blood*,  radiography,  ultrasonography
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Remarkable thickening of right atrial wall in subjects with cardiac amyloidosis complicated with sic...
Next Document:  Transient ischemic attack and electrocardiographic abnormalities revealing left ventricular noncompa...