Document Detail

The use of B-type natriuretic peptides in the detection of myocardial ischemia in settings with rapid access to coronary angiography.
MedLine Citation:
PMID:  17067699     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate serial measurements of B-type natriuretic peptide (BNP) and NT-proBNP levels in the detection of myocardial ischemia. A total of 62 consecutive male patients referred for stress echocardiography in a tertiary care cardiology center were enrolled. Inducible myocardial ischemia was detected in 15 patients (24%). BNP and NT-proBNP levels were significantly lower in patients with ischemia compared to those without ischemia throughout exercise testing and during recovery (p<0.05 for all comparisons). Major differences in baseline characteristics including age and higher incidence of comorbidities including hypertension and kidney disease in patients without ischemia apparently outweighed myocardial ischemia as trigger for BNP and NT-proBNP secretion. The same factors may have induced a selection bias in the decision to offer direct coronary angiography or initial stress testing. In conclusion, BNP and NT-proBNP are not helpful in the evaluation of male patients with suspected myocardial ischemia in a tertiary care cardiology center with rapid access to coronary angiography.
David Conen; Nikolaus Jander; Dietmar Trenk; Franz-Josef Neumann; Christian Mueller
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2006-10-24
Journal Detail:
Title:  International journal of cardiology     Volume:  119     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-25     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  416-8     Citation Subset:  IM    
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MeSH Terms
Cohort Studies
Coronary Angiography
Echocardiography, Stress
Middle Aged
Myocardial Ischemia / blood*,  radiography,  ultrasonography
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Reg. No./Substance:
0/Peptide Fragments; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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