| The use of 5,6 benzo-[alpha]-pyrone (coumarin) and heating by microwaves in the treatment of chronic lymphedema of the legs. | |
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MedLine Citation:
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PMID: 8897354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixty patients with leg lymphedema from a variety of etiologies were divided into randomized two groups, matched by Grade, duration, age, sex, and cause of lymphedema. Using a double-blind format, one group received 5,6 benzo-[alpha]-pyrone (coumarin 1,2 benzopyrone, 400 mg/day) for six months; the other received a placebo. For the next six months, both groups received a standardized regimen of heat (using microwaves) coupled with compression garments. Benzopyrone produced approximately 20% reduction in the volume (p = 10(-4)) and improvement in circumferences and tonometry (p = 10(-5) and 10(-7)). Symptoms (feelings of swelling, pain, heaviness and loss of mobility) were also significantly improved (p = 0.03 to 10(-7)). During the second six months, when microwave heat therapy was added to drug therapy, the patients who had previously received the placebo showed significant improvement (p = 0.03 to 10(-9)) in signs and symptoms of lymphedema. Some, but not all, of the group that was receiving benzopyrones were also significantly improved by heat therapy (p = 0.8 to 0.002). Taking benzopyrones for 12 months plus heat treatment for six months was significantly better, for some criteria, than the placebo plus heat therapy (p = 0.7 to 0.04). On the other hand, heat plus either placebo or benzopyrone was often significantly better than either the active or inactive drug without heat (p = 0.8 to 10(-9)). |
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Authors:
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T S Chang; J L Gan; K D Fu; W Y Huang |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Lymphology Volume: 29 ISSN: 0024-7766 ISO Abbreviation: Lymphology Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-02-14 Completed Date: 1997-02-14 Revised Date: 2006-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0155112 Medline TA: Lymphology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 106-11 Citation Subset: IM |
Affiliation:
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Department of Plastic & Reconstructive Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Anticoagulants / therapeutic use* Bandages Chronic Disease Combined Modality Therapy Coumarins / therapeutic use* Double-Blind Method Female Follow-Up Studies Humans Hyperthermia, Induced* Leg Lymphedema / therapy* Male Microwaves Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Coumarins; 91-64-5/coumarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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