| Is urodilatin the missing link in exercise-dependent renal sodium retention? | |
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MedLine Citation:
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PMID: 9451626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to investigate the behavior of plasma atrial natriuretic peptide [ANP-(99-126)] concentration ([ANP]) and renal urodilatin [Uro; ANP-(95-126)] excretion during and after exercise and their possible effects on renal Na+ retention. Ten male subjects performed a cycle ergometer test for 60 min at 60% of maximum workload. Blood and urine samples were collected before, during, and up to 24 h after exercise. During exercise, plasma [ANP] and renal Uro excretion were oppositely affected: whereas [ANP] increased from 46.5 +/- 5.1 to 124.1 +/- 10.6 pg/ml, urinary Uro excretion decreased from 120.8 +/- 16.0 to 49.5 +/- 9.8 fmol/min and remained at a lower level until 1 h after exercise. Glomerular filtration rate showed lowest values during exercise (from 164.9 +/- 15.3 to 75.8 +/- 10.1 ml/min), and urine flow and the fractional excretion rate of Na+ (FENa+) and Cl- (FECl-) had their nadir during the first hour after exercise. Positive relationships were observed between Uro excretion and FENa+ (P < 0.05) and FECl-, whereas a tendency toward a negative correlation was obtained between [ANP] and FENa+. It seems possible that Uro may be, among other factors, involved in the exercise-related regulation of renal Na+ retention. The specific roles Uro and ANP play during exercise, however, remain to be investigated. |
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Authors:
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W Schmidt; A Bub; M Meyer; T Weiss; G Schneider; N Maassen; W G Forssmann |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 84 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-03-20 Completed Date: 1998-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: IM |
Affiliation:
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Abteilung Sportmedizin/Sportphysiologie, Universität Bayreuth, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Natriuretic Factor / blood Blood Pressure / physiology Electrolytes / blood Exercise / physiology* Glomerular Filtration Rate / physiology Heart Rate / physiology Humans Kidney / metabolism* Kidney Function Tests Lactic Acid / blood Male Phenytoin / urine* Plasma Volume / physiology Sodium / urine* |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 50-21-5/Lactic Acid; 57-41-0/Phenytoin; 7440-23-5/Sodium; 85637-73-6/Atrial Natriuretic Factor |
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