| The urocortin 1 neurocircuit: ethanol-sensitivity and potential involvement in alcohol consumption. | |
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MedLine Citation:
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PMID: 16766036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the hallmarks of alcoholism is continued excessive consumption of alcohol-containing beverages despite the negative consequences of such behavior. The neurocircuitry regulating alcohol consumption is not well understood. Recent studies have shown that the neuropeptide urocortin 1 (Ucn1), a member of the corticotropin-releasing factor (CRF) family of peptides, could be an important player in the regulation of alcohol consumption. This evidence is accumulated along three directions of research: (1) Ucn 1-containing neurons are extremely sensitive to alcohol; (2) the Ucn1 neurocircuit may contribute to the genetic predisposition to high alcohol intake in mice and rats; (3) manipulation of the Ucn1 system alters alcohol consumption and sensitivity. This paper reviews the current knowledge of the Ucn1 neurocircuit and the evidence for its involvement in alcohol-related behaviors, and proposes a mechanism for its involvement in the regulation of alcohol consumption. |
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Authors:
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Andrey E Ryabinin; Adam Z Weitemier |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Brain research reviews Volume: 52 ISSN: 0165-0173 ISO Abbreviation: - Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-10-05 Completed Date: 2006-11-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101300366 Medline TA: Brain Res Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 368-80 Citation Subset: IM |
Affiliation:
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Department of Behavioral Neuroscience, Oregon Health and Science University, L470, 3181 SW Sam Jackson Park Road, Portland, 97239, USA. ryabinin@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol-Induced Disorders, Nervous System
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genetics,
metabolism,
physiopathology Alcoholism / genetics, metabolism*, physiopathology Animals Brain / anatomy & histology, drug effects, metabolism* Corticotropin-Releasing Hormone / genetics, metabolism* Disease Models, Animal Ethanol / pharmacology Genetic Predisposition to Disease / genetics* Humans Mice Models, Neurological Neural Pathways / anatomy & histology, drug effects, metabolism* Rats Urocortins |
| Grant Support | |
ID/Acronym/Agency:
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AA013484/AA/NIAAA NIH HHS; AA013738/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Urocortins; 64-17-5/Ethanol; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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