| Is urine interleukin-8 level a reliable laboratory test for diagnosing late onset sepsis in premature infants? | |
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MedLine Citation:
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PMID: 17596292 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study is aimed to determine serum and urine interleukin-8 (IL-8) levels in premature infants with late onset sepsis (LOS) and to evaluate if urine IL-8 is a useful test for LOS diagnosis. Fifty-six premature infants admitted to the NICU over 1 year had serum and urine IL-8 determined by ELISA. They were divided into three groups: I definite sepsis, II probable sepsis and III non-infected. Results were expressed as mean or median. Differences between groups were assessed by ANOVA, Kruskal-Wallis ANOVA and Dunn's Method. Sensitivity, specificity and positive and negative predictive values were calculated and a receiver operator characteristic curve was constructed to determine serum and urine IL-8 accuracy. There were no differences between groups for birth weight, and gestational and post-natal age. Median serum and urine IL-8 levels were significantly higher in GI and GII: 929 x 906 x 625 pg/ml; P = 0.024, and 249 x 189 x 42 pg/mgCr; P < 0.001. Optimal cut-off point was 625 pg/ml for serum IL-8 with 69% sensitivity and 75 pg/mgCr for urine IL-8 with 92% sensitivity. IL-8 can be determined in urine from premature infants with LOS and is an accurate and feasible diagnosis method. |
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Authors:
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Maria Regina Bentlin; Lígia Maria Suppo de Souza Rugolo; Antonio Rugolo Júnior; Míriam Hashimoto; João César Lyra |
Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2007-06-27 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 53 ISSN: 0142-6338 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-25 Completed Date: 2008-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 403-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University Hospital, Botucatu School of Medicine, São Paulo State University, Brazil. mbentlin@fmb.unesp.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Biological Markers / blood, urine Humans Infant, Newborn Infant, Premature* Interleukin-8 / blood, urine* ROC Curve Sensitivity and Specificity Sepsis / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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