Document Detail

Is urine interleukin-8 level a reliable laboratory test for diagnosing late onset sepsis in premature infants?
MedLine Citation:
PMID:  17596292     Owner:  NLM     Status:  MEDLINE    
The present study is aimed to determine serum and urine interleukin-8 (IL-8) levels in premature infants with late onset sepsis (LOS) and to evaluate if urine IL-8 is a useful test for LOS diagnosis. Fifty-six premature infants admitted to the NICU over 1 year had serum and urine IL-8 determined by ELISA. They were divided into three groups: I definite sepsis, II probable sepsis and III non-infected. Results were expressed as mean or median. Differences between groups were assessed by ANOVA, Kruskal-Wallis ANOVA and Dunn's Method. Sensitivity, specificity and positive and negative predictive values were calculated and a receiver operator characteristic curve was constructed to determine serum and urine IL-8 accuracy. There were no differences between groups for birth weight, and gestational and post-natal age. Median serum and urine IL-8 levels were significantly higher in GI and GII: 929 x 906 x 625 pg/ml; P = 0.024, and 249 x 189 x 42 pg/mgCr; P < 0.001. Optimal cut-off point was 625 pg/ml for serum IL-8 with 69% sensitivity and 75 pg/mgCr for urine IL-8 with 92% sensitivity. IL-8 can be determined in urine from premature infants with LOS and is an accurate and feasible diagnosis method.
Maria Regina Bentlin; Lígia Maria Suppo de Souza Rugolo; Antonio Rugolo Júnior; Míriam Hashimoto; João César Lyra
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-06-27
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  53     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-25     Completed Date:  2008-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  403-8     Citation Subset:  IM    
Department of Pediatrics, University Hospital, Botucatu School of Medicine, São Paulo State University, Brazil.
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MeSH Terms
Analysis of Variance
Biological Markers / blood,  urine
Infant, Newborn
Infant, Premature*
Interleukin-8 / blood,  urine*
ROC Curve
Sensitivity and Specificity
Sepsis / diagnosis*
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-8

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