Document Detail


An urgent problem of aerobic gram-negative pathogen infection in complicated parapneumonic effusions or empyemas.
MedLine Citation:
PMID:  17675765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Complicated parapneumonic effusion or empyema is a troublesome disease with a high mortality. The most common involved microorganisms seem to have changed over recent decades, influenced by the introduction of new antibiotics, and the increase of immunocompromised hosts, and the elderly population. More epidemiological studies on the current bacteriology are needed to help us to empirically select adequate antibiotics. DESIGN: A retrospective study via chart review in a university-affiliated tertiary medical center was conducted to assess the underlying bacterial pathogens and outcome of patients with complicated parapneumonic effusions or empyemas. RESULTS: During the 43-month study period (from December 2000 to June 2004), 304 patients were diagnosed with complicated parapneumonic effusions or empyemas and the mortality of these patients was 23% (69/304). Among these 304 patients, a total of 292 microorganisms were cultured from the pleural fluid samples of 207 patients (to yield a positive microbiological culture rate of 68% (207/304). Isolated bacteria included aerobic Gram-negative bacteria (n=129), aerobic Gram-positive bacteria (n=105), anaerobic bacteria (n=51), and M. tuberculosis (n=7). Of these aerobic bacterial infections, Gram-negative bacteria were isolated more frequently from the older population and involved a significantly higher mortality rate and longer stay, compared to those with other bacteria (p=0.001 and p<0.001 respectively). CONCLUSION: The increasing incidence of infection with aerobic Gram-negative pathogens may cause more critical conditions in complicated parapneumonic effusions or empyemas.
Authors:
Yu-Chao Lin; Chih-Yen Tu; Wei Chen; Yu-Lin Tsai; Hung-Jen Chen; Wu-Huei Hsu; Chuen-Ming Shih
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Publication Detail:
Type:  Journal Article     Date:  2007-08-02
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  46     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-06     Completed Date:  2007-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1173-8     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Empyema, Pleural / microbiology*
Female
Hospital Mortality
Humans
Klebsiella Infections / complications*,  diagnosis
Klebsiella pneumoniae / pathogenicity
Male
Middle Aged
Pleural Effusion / microbiology*
Prevalence
Proteus / pathogenicity
Proteus Infections / complications*,  diagnosis
Pseudomonas Infections / complications*,  diagnosis
Pseudomonas aeruginosa / pathogenicity
Retrospective Studies

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