| The uptake of oestrone from the lumen of the isolated perfused rat gut. | |
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MedLine Citation:
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PMID: 1897249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. In the isolated perfused rat gut oestrone was not taken up from the perfusate but was rapidly taken up from the gut lumen when administered in dimethyl sulphoxide or in 10% acetone in water. 2. Uptake from corn oil was much slower and the rate was concentration-dependent. 3. When given in dimethyl sulphoxide or in aqueous acetone, the residual oestrone in the gut lumen was largely unchanged, with only about 10% being present as the glucuronide. Of the oestrone in the gut perfusate, some 40% was glucuronidated. 4. No evidence was obtained for any reduction or hydroxylation, or for any sulphation, during uptake of oestrone by the gut. 5. No secretion of oestrone or its metabolites into lymph could be detected. |
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Authors:
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A B Roy; C G Curtis; H Hughes |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 21 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 491-8 Citation Subset: IM |
Affiliation:
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Protein Chemistry Group, John Curtin School of Medical Research, Canberra, ACT, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Chromatography, Gel Estrone / metabolism* Intestines / metabolism* Liver / metabolism Lymph / metabolism Male Perfusion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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53-16-7/Estrone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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