Document Detail

Lactate/H+ uptake by red blood cells during exercise alters their physical properties.
MedLine Citation:
PMID:  9007458     Owner:  NLM     Status:  MEDLINE    
We investigated whether uptake of lactate anions by red blood cells (RBC) during maximal exercise altered certain cellular physical properties including volume, density and osmotic fragility. Irrespective of whether individuals undertook 1 min of exercise at maximal effort or a progressive exercise test to exhaustion, whole-blood lactate concentration increased about tenfold relative to pre-exercise values (P < 0.001). The plasma and cellular concentrations of lactate increased uniformly, which maintained a constant plasma-to-cell gradient. Exercise-induced increases in RBC osmotic fragility (P < 0.001) and mean cell volume (MCV; P < 0.05), and decreases in mean cell haemoglobin concentration (MCHC; P < 0.05) and cell density (P < 0.005) also occurred. These exercise-induced cellular responses could be simulated in vitro by treating blood with L-lactic acid (15 mM), but not by low pH (7.1) or L-lactate alone. The uptake of lactate by RBCs during vigorous exercise alters certain cellular properties. Although the physiological implications of these changes are unclear, the traditional view that the lactate anion has no known harmful effects should be reconsidered.
J A Smith; R D Telford; M Kolbuch-Braddon; M J Weidemann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  75     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1997  
Date Detail:
Created Date:  1997-03-28     Completed Date:  1997-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  54-61     Citation Subset:  IM    
Department of Human Performance and Health Promotion, University of New Orleans, LA 70148, USA.
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MeSH Terms
Cell Size
Erythrocyte Indices
Erythrocytes / physiology*
Exercise / physiology*
Hydrogen-Ion Concentration
Lactic Acid / blood*
Osmotic Fragility
Reg. No./Substance:
0/Anions; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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