Document Detail

The uptake of amino acids and oxygen across the rabbit uterus in normal and postterm pregnancies.
MedLine Citation:
PMID:  2288997     Owner:  NLM     Status:  MEDLINE    
Nineteen pregnant rabbits were studied at three different gestational ages in terms of uterine uptake of amino acids and oxygen under unstressed, steady-state conditions. The three gestational age groups were: (1) 23-25 days, (2) 26-31 days, and (3) 32-34 days (post term). The arteriovenous differences for all amino acids except glutamate and aspartate were significant in groups 1 and 2. Uterine amino acid coefficients of extraction were markedly reduced in the postterm animals (3), despite an increased uterine coefficient of extraction for oxygen. The uterine coefficients of extraction of amino acids were 2-2.5 times greater than those across the pregnant Uterus of the sheep. There was also an increased uptake of amino acid per millimoles/liter of oxygen in the rabbit compared to the sheep. Maternal arterial amino acid concentrations were not significantly different in groups 1 and 2, but the gluconeogenic amino acids serine and alanine were significantly increased in maternal arterial blood of postterm animals.
H Q Li; M Gilbert; C Teng; R O Jones; R D Murray; F C Battaglia
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  58     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-03     Completed Date:  1991-04-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Department of Pediatrics, University of Colorado, School of Medicine, Denver.
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MeSH Terms
Amino Acids / blood,  metabolism*
Blood Specimen Collection
Body Weight
Fetus / anatomy & histology
Gestational Age
Organ Size
Oxygen / blood*
Placenta / anatomy & histology,  metabolism*
Pregnancy, Animal / blood,  physiology*
Pregnancy, Prolonged
Rabbits / physiology*
Sheep / physiology
Uterus / blood supply,  metabolism*,  surgery
Grant Support
Reg. No./Substance:
0/Amino Acids; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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