Document Detail

The uptake of 3H-dexamethasone during phagocytosis of Staphylococcus aureus by Human neutrophils.
MedLine Citation:
PMID:  757535     Owner:  NLM     Status:  MEDLINE    
In the normal human neutrophil under basal resting conditions, cell-associated levels of 3H-dexamethasone (3H-DXM) increased in a linear fashion following addition of the drug. However, during phagocytosis of 14C-labelled Staphylococcus aureus (Staph. aureus), the intracellular 3H-DXM levels rose above basal concentrations in direct relation to the quantity of ingested organisms. The observation that the cell-associated activity of 3H-DSM rises in a parallel fashion to the quantity of ingested Staph. aureus must be recognized and taken into consideration as a variable, when assessing the results between resting and activated phases of neutrophil function in the presence of glucocorticoids.
J M Mishler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haematologia     Volume:  12     ISSN:  0017-6559     ISO Abbreviation:  Haematologia (Budap)     Publication Date:    1978-1979
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  0130266     Medline TA:  Haematologia (Budap)     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
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MeSH Terms
Binding Sites
Cell Membrane / metabolism
Dexamethasone / metabolism*,  physiology
Neutrophils / metabolism*,  physiology
Staphylococcus aureus / metabolism*
Time Factors
Reg. No./Substance:
10028-17-8/Tritium; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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