| The ups and downs of heart rate. | |
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MedLine Citation:
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PMID: 22179340 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: : To review the physiology of the regulation and determinants of heart rate and the significance in the management of critically ill patients. DATA SOURCES: : The MEDLINE database, references from selected articles, and the author's personal database. DATA SYNTHESIS: : This review begins with the regulation of cardiac output and heart rate during exercise because this demonstrates the range of physiological responses in the normal human. This analysis shows that change in heart rate is a major component of the cardiovascular system's ability to adjust cardiac output and a number of regulatory systems control heart rate. When heart rate responses are limited because of disease or pharmacologic reasons, changes in stroke volume must compensate, but the capacity to do so is limited by the passive filling characteristics of the ventricles. On the other side, high heart rates increase myocardial oxygen demand, which can be a problem in patients with fixed coronary artery disease. CONCLUSION: : Heart rate must be interpreted in the context of the patient's overall hemodynamic condition. The prudent physician must ask why is the heart rate high, what will be achieved by lowering the heart rate, and, finally, what are the consequences of lowering the heart rate? |
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Authors:
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Sheldon A Magder |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical care medicine Volume: 40 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 239-45 Citation Subset: AIM; IM |
Affiliation:
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From the McGill University Health Centre, Montreal, Quebec, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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