| An update on the use of NOD mice to study autoimmune (Type 1) diabetes. | |
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MedLine Citation:
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PMID: 20979558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes mellitus shares multiple characteristics with the human disease, and studies employing this model continue to yield clinically relevant and important information. Here, we review some of the recent key findings obtained from NOD mouse investigations that have both advanced our understanding of disease pathogenesis and suggested new therapeutic targets and approaches. Areas discussed include antigen discovery, identification of genes and pathways contributing to disease susceptibility, development of strategies to image islet inflammation and the testing of therapeutics. We also review recent technical advances that, combined with an improved understanding of the NOD mouse model's limitations, should work to ensure its popularity, utility and relevance in the years ahead. |
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Authors:
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Rodolfo José Chaparro; Teresa P Dilorenzo |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Expert review of clinical immunology Volume: 6 ISSN: 1744-8409 ISO Abbreviation: Expert Rev Clin Immunol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-05-24 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101271248 Medline TA: Expert Rev Clin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 939-55 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantigens / immunology* Diabetes Mellitus, Type 1 / drug therapy, genetics, immunology* Disease Models, Animal Drug Discovery Genetic Predisposition to Disease Humans Immunologic Techniques / trends Mice Mice, Inbred NOD* |
| Grant Support | |
ID/Acronym/Agency:
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NS07098/NS/NINDS NIH HHS; R01 DK064315/DK/NIDDK NIH HHS; R01 DK064315-08/DK/NIDDK NIH HHS; R56 AI088256/AI/NIAID NIH HHS; R56 AI088256-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantigens |
| Comments/Corrections | |
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