Document Detail


An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination.
MedLine Citation:
PMID:  23632257     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The determination of human mitochondrial DNA (mtDNA) haplogroups is not only crucial in anthropological and forensic studies, but is also helpful in the medical field to prevent the making of wrong disease associations. In recent years, high-throughput technologies and the huge amounts of data they create, as well as the regular updates to the mtDNA phylogenetic tree, mean there is a need for an automated approach which can make a speedier determination of haplogroups than can be made by using the traditional manual method. Here, we update the MitoTool (www.mitotool.org) by incorporating a novel scoring system for the determination of mtDNA into haplogroups, which has advantages on speed, accuracy and ease of implementation. In order to make the access to MitoTool easier, we also provide a stand-alone version of the program that will run on a local computer and this version is freely available at the MitoTool website.
Authors:
Long Fan; Yong-Gang Yao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-27
Journal Detail:
Title:  Mitochondrion     Volume:  -     ISSN:  1872-8278     ISO Abbreviation:  Mitochondrion     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-5-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. Electronic address: mitotool@gmail.com.
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